Pancreatic Acinar Cell Carcinoma with Germline BRCA2 Mutation and Severe Pancreatic Panniculitis: A Case Report
| Autor: | Tianzuo Zhan, Philip Weidner, Nadine Schulte, Christoph Reissfelder, Lena Dreikhausen, Johannes Moersdorf, Sebastian Belle, Matthias P. Ebert |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
FOLFIRINOX medicine.medical_treatment Gastroenterology Case Report Multimodal therapy medicine.disease Olaparib Targeted therapy chemistry.chemical_compound Germline mutation Breast cancer chemistry PARP inhibitor Cancer research Medicine Surgery business Pancreatic Acinar Cell Carcinoma |
| Zdroj: | Visc Med |
| ISSN: | 2297-475X 2297-4725 |
| Popis: | Pancreatic acinar cell carcinoma (ACC) is a rare malignant disease that displays distinct differences to pancreatic ductal adenocarcinoma. Here, we report the case of a patient with ACC and underlying breast cancer susceptibility gene 2 (BRCA2) germline mutation that developed severe pancreatic panniculitis (PP) during the course of the disease. The patient received a multimodal therapy including surgery, systemic chemotherapy, and targeted therapy with the PARP inhibitor olaparib, resulting in an overall survival of 47 months. Findings from this case are compared to the current knowledge on management of ACC and paraneoplastic PP. |
| Databáze: | OpenAIRE |
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