Prevalence of reticular pseudodrusen in newly presenting adult onset foveomacular vitelliform dystrophy
| Autor: | Winfried M Amoaku, Craig Wilde, Arun Lakshmanan, Marco U Morales, M Patel, Sushma Dhar-Munshi |
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| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty genetic structures Retinal Drusen Vitelliform macular dystrophy Multimodal Imaging 03 medical and health sciences 0302 clinical medicine Geographic Atrophy Ophthalmology Photography Prevalence medicine Humans Fluorescein Angiography Aged Retrospective Studies Retinal drusen Multimodal imaging business.industry Dystrophy medicine.disease eye diseases Vitelliform Macular Dystrophy Ocular oncology Geographic atrophy Reticular pseudodrusen Angioid streaks 030104 developmental biology Clinical Study 030221 ophthalmology & optometry Angioid Streaks Female business Tomography Optical Coherence |
| Zdroj: | Eye. 30:817-824 |
| ISSN: | 1476-5454 0950-222X |
| Popis: | PurposeTo report the association and prevalence of reticular pseudodrusen (RPD) in eyes with newly presenting adult onset foveomacular vitelliform dystrophy (AFVD). To compare the strength of association with other pathologies resulting from dysfunction of the choroid-Bruch's membrane-retinal pigment epithelium (RPE) complex, including eyes with geographic atrophy (GA) and angioid streaks.MethodsRetrospective single-centre review of all consecutive newly presenting AFVD. Multimodal imaging with spectral domain optical coherence tomography, fundus photographs, red-free/blue light images, and fundus fluorescein angiograms were graded for the presence of RPD. For comparison, all consecutive newly presenting cases of GA and eyes with angioid streaks were studied.ResultsFifteen (15) patients were identified with AFVD (mean age of 77.3 years; 73.3% female). Mean age of patients with AFVD and RPD was 80.5 years (SD 3.7), whereas that of patients with AFVD without RPD was 75.1 years (SD 7.0). This age difference did not reach statistical significance, P=0.1. Six (40%) had identifiable RPD; being a bilateral finding in 100% of patients. No males with AFVD and RPD were identified. A total of 92 eyes presented with GA. Twenty-three (23) of these (25.0%) had RPD. Twelve (12) patients presented with identifiable angioid streaks, with 4 (36.4%) having RPD.ConclusionRPD are a frequent finding in eyes with newly presenting AFVD; not being restricted to AMD, but a finding common among diseases where pathophysiological mechanisms involve damage to Bruch's membrane and the RPE, whether genetic or degenerative. Our study supports the concept that they occur with high but variable frequencies in eyes with various pathologies. |
| Databáze: | OpenAIRE |
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