Mapping the effects of the selective dopamine D2/D3 receptor agonist quinelorane using pharmacological magnetic resonance imaging
| Autor: | R. A. Leslie, Andrew S. Lowe, Steven Williams, Charlie Reavill, M F James, M. F. Ireland |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Agonist medicine.medical_specialty Quinelorane medicine.drug_class Striatum Motor Activity Nucleus accumbens Rats Sprague-Dawley chemistry.chemical_compound Dopamine receptor D3 Dopamine receptor D2 Internal medicine Image Processing Computer-Assisted medicine Animals Receptor 7-OH-DPAT Brain Mapping Dose-Response Relationship Drug Receptors Dopamine D2 General Neuroscience Receptors Dopamine D3 Magnetic Resonance Imaging Rats Oxygen Endocrinology chemistry Dopamine Agonists Quinolines |
| Zdroj: | Neuroscience. 133:315-326 |
| ISSN: | 0306-4522 |
| DOI: | 10.1016/j.neuroscience.2005.02.018 |
| Popis: | Dopamine agonists with a high affinity for D 2 and D 3 receptors have a biphasic effect on rodent locomotion, inducing hypolocomotion at low doses and hyperlocomotion at higher doses. Controversy surrounds the role of the D 3 receptor in mediating the hypolocomotor response to low agonist doses. This study examines patterns of neuronal activation induced by varying doses of the D 2 /D 3 receptor agonist quinelorane using blood oxygen level dependent (BOLD) pharmacological magnetic resonance imaging (phMRI), and compares them with corresponding behavioural responses. Quinelorane (3 μg/kg) induced hypolocomotion in rats naive to the testing environment, and in phMRI experiments increased neuronal activity within the anterior olfactory nuclei, nucleus accumbens and islets of Calleja, regions containing a high density of D 3 receptors. A 30 μg/kg dose of quinelorane resulted in biphasic locomotor effects, with initial hypolocomotion followed by sustained hyperlocomotion. phMRI indicated that this higher dose increased cerebral activity within limbic and olfactory regions, as did the lower drug dose, but induced additional activation in the caudate-putamen and globus pallidus, areas dense in D 2 receptors but containing few D 3 receptors. The more restricted pattern of activation at low agonist doses and close temporal relationship between behavioural and BOLD signal responses to quinelorane suggest that those nuclei most dense in D 3 receptors play a key role in mediating the hypolocomotor effects of quinelorane. However, the presence of D 3 receptors in activated brain regions may be coincidental, and further studies are required to show definitively which class of receptors mediates agonist-induced hypolocomotion. In contrast, the activation of D 2 receptors within the striatum appears necessary for quinelorane-induced hyperlocomotion. |
| Databáze: | OpenAIRE |
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