Autoantibodies persist in relatives to systemic lupus erythematosus patients during 12 years follow-up
| Autor: | Henrik Langkilde, Niels H. H. Heegaard, Anne Voss, Helle Laustrup |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Time Factors Population based Autoimmune Diseases Arthritis Rheumatoid 03 medical and health sciences 0302 clinical medicine Rheumatology immune system diseases Prevalence medicine Humans Lupus Erythematosus Systemic Family 030212 general & internal medicine skin and connective tissue diseases Aged Autoantibodies 030203 arthritis & rheumatology Autoimmune disease Lupus erythematosus business.industry Age Factors Autoantibody Middle Aged medicine.disease Increased risk Antibodies Antinuclear Immunology Female business Follow-Up Studies |
| Zdroj: | Langkilde, H, Voss, A, Heegaard, N & Laustrup, H 2017, ' Autoantibodies persist in relatives to systemic lupus erythematosus patients during 12 years follow-up ', Lupus, vol. 26, no. 7, pp. 723-728 . https://doi.org/10.1177/0961203316676378 |
| ISSN: | 1477-0962 0961-2033 |
| Popis: | Background Systemic lupus erythematosus (SLE) is an autoimmune disease with presence of autoantibodies and characteristic multi-organ involvement. Relatives of SLE patients have an increased risk of autoantibody production and autoimmune diseases. Methods In 2001, 226 first degree relatives (FDRs) of a population-based cohort of SLE patients were examined for the prevalence of autoantibodies and self-reported health complaints. In 2013, 143 FDRs were re-investigated and deceased’s medical records were examined. Results Participants and non-participants were comparable regarding baseline characteristics, while deceased FDRs were older than participants, but with comparable ANA status. ANA status at baseline correlated to ANA status at follow-up. At follow-up, two FDRs reported SLE and 15 FDRs other autoimmune diseases. No observation at baseline alone could predict self-reported health. During follow-up 33 died at median age 76 years. Three deceased FDRs were diagnosed with an autoimmune disease. Conclusion The study showed that FDRs of SLE patients have an increased prevalence of ANA compared to healthy controls. The prevalence increased during follow-up, and ANA positive FDRs at baseline were prone to be ANA positive at follow-up. ANA positive FDRs had more self-reported autoimmune diseases, including SLE and rheumatoid arthritis, than reported from other population-based investigations. |
| Databáze: | OpenAIRE |
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