Acromegalic osteopathy
| Autor: | Mazziotti, G., Maffezzoni, F., Frara, S., Giustina, A. |
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| Přispěvatelé: | Mazziotti, G., Maffezzoni, F., Frara, S., Giustina, A. |
| Rok vydání: | 2016 |
| Předmět: |
Human Growth Hormone
Endocrinology Diabetes and Metabolism Osteoporosi 030209 endocrinology & metabolism IGF-I Fractures Bone 03 medical and health sciences Fracture 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Acromegaly Humans Osteoporosis Insulin-Like Growth Factor I Growth hormone Human |
| Zdroj: | Pituitary. 20:63-69 |
| ISSN: | 1573-7403 1386-341X |
| DOI: | 10.1007/s11102-016-0758-6 |
| Popis: | Acromegalic osteopathy is an emerging complication of acromegaly characterized by increase in bone turnover, deterioration in bone microarchitecture and high risk of vertebral fractures. Vertebral fractures, as diagnosed by a radiological and morphometric approach, occur in about one-third of acromegaly patients in close relationship with duration of active disease. However, the prediction of vertebral fractures in this clinical setting is still a matter of uncertainty, since the pathogenesis of acromegalic osteopathy is multifactorial and fractures may occur even in presence of normal bone mineral density. In this narrative article, we summarize the pathophysiology and clinical aspects of acromegalic osteopathy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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