Quantitative determination of migrating compounds from plastic baby bottles by validated GC-QqQ-MS and LC-QqQ-MS methods
| Autor: | Joris Van Loco, Noelia Negreira, Matthias Onghena, Adrian Covaci, Els Van Hoeck, Laurent Quirynen |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Lc qqq ms
Reproducibility Chromatography Chemistry Pharmacology. Therapy 010401 analytical chemistry Extraction (chemistry) Analytical chemistry 04 agricultural and veterinary sciences Repeatability 040401 food science 01 natural sciences Applied Microbiology and Biotechnology Quantitative determination 0104 chemical sciences Analytical Chemistry 0404 agricultural biotechnology media_common.cataloged_instance European union Safety Risk Reliability and Quality Safety Research Volume concentration Food Science media_common |
| Zdroj: | Food analytical methods |
| ISSN: | 1936-9751 |
| Popis: | Following the recent prohibition on the use of BPA for the production of polycarbonate (PC) baby bottles in the European Union, baby bottles made of alternative materials, such as polypropylene, polyethersulphone, polyamide, Tritan (TM) or silicone, have appeared in the market. An initial study done in previous work applying a liquid-liquid extraction (LLE) followed by GC-MS analysis identified a wide variety of migrating compounds. Based on these screening results, the monitoring and quantification of the most important migrating compounds was further pursued. We describe the optimisation, validation and application of an LLE method for the extraction of these migrating compounds adapted to low concentrations. Generally, absolute recoveries between 70 and 110 % with RSDs < 20 % were obtained. Further, specific and quantitative GC-QqQ-MS and LC-QqQ-MS methods were developed and validated by evaluating the following parameters: sensitivity, selectivity, linearity, accuracy, precision, recoveries and matrix effects. Limits of quantification (LOQs) ranged between 0.6 and 8 mu g kg(-1) for the majority of the selected compounds. Linearity ranged using Mandel's fitting test between coefficients of determination (R (2)) of 0.995 and 0.999. Both repeatability and reproducibility were demonstrated to be satisfactory considering the Horwitz equation. Finally, the methods were applied on a selection of baby bottles representative for the Belgian market. Several compounds previously identified by the screening approach were confirmed and adequately quantified. For instance, azacyclotridecan-2-one had a maximum migration value of 1091 mu g kg(-1) whereas 4-propylbenzaldehyde migrated at 27 mu g kg(-1) and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB) at 348 mu g kg(-1). However, most of the targeted compounds were not detected or below the LOQ. |
| Databáze: | OpenAIRE |
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