Anti-TNF-α therapy may cause neonatal neutropenia
| Autor: | Sophie Candon, Laure Croisille, Loïc de Pontual, Tewfik Bibi Triki, Marie-Louise Frémond, Tamazoust Guiddir, Thierry Leblanc |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Neutropenia Neonatal Neutropenia Young Adult Pregnancy medicine Humans business.industry Tumor Necrosis Factor-alpha Autoantibody Infant Newborn Antibodies Monoclonal medicine.disease Ulcerative colitis Infliximab Autoimmune neutropenia Prenatal Exposure Delayed Effects Pediatrics Perinatology and Child Health Immunology Absolute neutrophil count Female business medicine.drug |
| Zdroj: | Pediatrics. 134(4) |
| ISSN: | 1098-4275 |
| Popis: | Although anti–tumor necrosis factor (anti-TNF) antibodies are associated with a clear risk of agranulocytosis in adults and are known to cross the placenta, monitoring of the absolute neutrophil count (ANC) in neonates born to mothers receiving these biological agents is not currently recommended. Here, we report on the first case series of 4 newborn patients with severe neutropenia born to mothers treated for ulcerative colitis with infliximab during pregnancy (including the third trimester). The newborns presented with severe neutropenia at birth, which was subsequently complicated by skin infections. The newborns' ANCs returned to the normal range within 8 to 14 weeks, at which time infliximab could not be detected in the blood. Anti-TNF agents probably exert a direct, toxic effect on the bone marrow. Furthermore, the detection of a CD16 autoantibody in 1 mother-newborn pair suggests that infliximab can induce autoimmune neutropenia. Abnormally high levels of the CD16 autoantibody in newborn serum or immaturity of the fetal bone marrow might explain why neutropenia was observed in the child but not in the mother. We recommend the systematic measurement of ANC on cord blood at birth and (in the event of an infection) in the weeks thereafter. |
| Databáze: | OpenAIRE |
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