Milk protein intake, the metabolic-endocrine response, and growth in infancy: Data from a randomized clinical trial
Autor: | Piotr, Socha, Veit, Grote, Dariusz, Gruszfeld, Roman, Janas, Hans, Demmelmair, Ricardo, Closa-Monasterolo, Joaquín Escribano, Subías, Silvia, Scaglioni, Elvira, Verduci, Elena, Dain, Jean-Paul, Langhendries, Emmanuel, Perrin, Berthold, Koletzko, Fiammetta, Vecchi |
---|---|
Jazyk: | angličtina |
Rok vydání: | 2011 |
Předmět: |
Blood Glucose
Male medicine.medical_specialty medicine.medical_treatment Urinary system Medicine (miscellaneous) Endocrine System Urine White People chemistry.chemical_compound Child Development Double-Blind Method Risk Factors Internal medicine medicine Animals Humans Obesity Insulin-Like Growth Factor I chemistry.chemical_classification Creatinine Nutrition and Dietetics C-Peptide C-peptide business.industry Insulin Infant RNA-Binding Proteins Sciences bio-médicales et agricoles Milk Proteins Amino acid Endocrinology Breast Feeding Insulin-Like Growth Factor Binding Protein 3 Milk chemistry Urea Female business Energy Intake Breast feeding Amino Acids Branched-Chain Biomarkers |
Zdroj: | The American journal of clinical nutrition, 94 (6 |
Popis: | Background: Protein intake in early infancy has been suggested to be an important risk factor for later obesity, but information on potential mechanisms is very limited. Objective: This study examined the influence of protein intake in infancy on serum amino acids, insulin, and the insulin-like growth factor I (IGF-I) axis and its possible relation to growth in the first 2 y of life. Design: In a multicenter European study, 1138 healthy, formula-fed infants were randomly assigned to receive cow-milk-based infant and follow-on formulas with lower protein (LP; 1.77 and 2.2 g protein/100 kcal) or higher protein (HP; 2.9 and 4.4 g protein/100 kcal) contents for the first year. Biochemical variables were measured at age 6 mo in 339 infants receiving LP formula and 333 infants receiving HP formula and in 237 breastfed infants. Results: Essential amino acids, especially branched-chain amino acids, IGF-I, and urinary C-peptide:creatinine ratio, were significantly (P < 0.001) higher in the HP group than in the LP group, whereas IGF-binding protein (IGF-BP) 2 was lower and IGF-BP3 did not differ significantly. The median IGF-I total serum concentration was 48.4 ng/mL (25th, 75th percentile: 27.2, 81.8 ng/mL) in the HP group and 34.7 ng/mL (17.7, 57.5 ng/mL) in the LP group; the urine C-peptide:creatinine ratios were 140.6 ng/mg (80.0, 203.8 ng/mg) and 107.3 ng/mg (65.2, 194.7 ng/mg), respectively. Most essential amino acids, IGF-I, C-peptide, and urea increased significantly in both the LP and HP groups compared with the breastfed group. Total IGF-I was significantly associated with growth until 6 mo but not thereafter. Conclusions: HP intake stimulates the IGF-I axis and insulin release in infancy. IGF-I enhances growth during the first 6 mo of life. This trial was registered at clinicaltrials.gov as NCT00338689. © 2011 American Society for Nutrition. SCOPUS: cp.j info:eu-repo/semantics/published |
Databáze: | OpenAIRE |
Externí odkaz: |