Myocardial m6A regulators in postnatal development: effect of sex

Autor:	D, Semenovykh, D, Benak, K, Holzerova, B, Cerna, P, Telensky, T, Vavrikova, F, Kolar, J, Neckar, M, Hlavackova
Rok vydání:	2022
Předmět:	Physiology Short Communication General Medicine
Zdroj:	Physiol Res
ISSN:	1802-9973 0862-8408
DOI:	10.33549/physiolres.934970
Popis:	N6-methyladenosine (m6A) is an abundant mRNA modification affecting mRNA stability and protein expression. It is a highly dynamic process, and its outcomes during postnatal heart development are poorly understood. Here we studied m6A machinery in the left ventricular myocardium of Fisher344 male and female rats (postnatal days one to ninety; P1-P90) using Western Blot. A downward pattern of target protein levels (demethylases FTO and ALKBH5, methyltransferase METTL3, reader YTHDF2) was revealed in male and female rat during postnatal development. On P1, the FTO protein level was significantly higher in male compared to females.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4949a37e57fb2984351c8718b4626b76 https://doi.org/10.33549/physiolres.934970 Zobrazit plný text záznamu