Generalized Bullous Fixed Drug Eruption to Fluconazole with Positive Patch Testing and Confirmed Tolerance to Itraconazole
| Autor: | Zoi Tsakiraki, Evangelia Papadavid, Anna Syrmali, Christos Fokoloros, Vasileia Damaskou, Michael Makris |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Drug medicine.medical_specialty Antifungal Agents Itraconazole media_common.quotation_subject Provocation test Scars Drug-related side effects and adverse reactions Patch tests Candidiasis Oral medicine Humans Immunology and Allergy Fluconazole Aged media_common business.industry Patch test Drug Tolerance Gold standard (test) medicine.disease Dermatology Drug eruption Medicine Cross reactions Drug Eruptions medicine.symptom business medicine.drug |
| Zdroj: | Iranian Journal of Allergy, Asthma and Immunology, Vol 20, Iss 2 (2021) |
| ISSN: | 1735-5249 1735-1502 |
| Popis: | Generalized bullous fixed drug eruption (GBFDE) is a specific variant of fixed drug eruption that belongs to severe cutaneous adverse reactions (SCARs) and its diagnosis is based mainly on clinical course and especially on the reoccurrence of typical bullous lesions in previous and new sites after re-administration of the offending drug. We present a well-documented case of fluconazole-induced GBFDE, with a positive patch test to fluconazole (30% weight/volume preparation) and clinical tolerance to itraconazole proven by negative oral provocation. Even in SCARs, patch testing represents a useful diagnostic tool, while oral provocation remains the gold standard in cases that an alternative but the chemically relevant drug must be administered. |
| Databáze: | OpenAIRE |
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