Preoperative risk stratification for cancer-specific survival of patients with upper urinary tract urothelial carcinoma treated by nephroureterectomy
| Autor: | Yasutomo Nakai, Kiyomi Matsumiya, Seiji Yamaguchi, Mototaka Sato, Go Tanigawa, Norio Nonomura, Hiroshi Kiuchi, Wataru Nakata, Motohide Uemura, Yoshiyuki Yamamoto, Kazutoshi Fujita, Akira Nagahara |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Risk Urologic Neoplasms medicine.medical_specialty Multivariate analysis Lymphovascular invasion Urology Nephrectomy Hemoglobins medicine Humans Stage (cooking) Pathological Aged Retrospective Studies Urothelial carcinoma Upper urinary tract Aged 80 and over Univariate analysis business.industry Sodium Hematology General Medicine Middle Aged Prognosis Surgery C-Reactive Protein Oncology Multivariate Analysis T-stage Female business |
| Zdroj: | International Journal of Clinical Oncology. 20:156-163 |
| ISSN: | 1437-7772 1341-9625 |
| DOI: | 10.1007/s10147-014-0695-1 |
| Popis: | This study aimed to identify preoperative parameters for predicting cancer-specific survival (CSS) in patients with upper urinary tract urothelial carcinoma (UTUC) who have undergone radical nephroureterectomy (RNU). The preoperative clinical and laboratory records of 357 UTUC patients who underwent RNU at three different institutions were retrospectively reviewed (256, training set; 101, test set). Univariate and multivariate analyses were performed on the training set data to identify preoperative prognostic factors, using which a risk stratification model was developed. The model was validated using test set data. In univariate analysis, clinical T stage classification and preoperative concentrations of hemoglobin, C-reactive protein, sodium, and albumin showed significant association with CSS. Multivariate analysis showed that low preoperative sodium and hemoglobin concentrations were significantly associated with a poor prognosis. A risk stratification model was developed using the preoperative sodium ( |
| Databáze: | OpenAIRE |
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