Anti-diabetic activity of traditional Indian gold containing preparation: Shadguna Balijarita Makaradhwaja on streptozotocin induced diabetic rats
| Autor: | Sanjay Khedekar, Galib Rukkudin, B Ravishankar, Pradeepkumar Prajapati |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Blood sugar Anti-diabetic activity Tinospora cordifolia Toxicology 03 medical and health sciences chemistry.chemical_compound Kupipakwa Rasayana Diabetes mellitus medicine Pharmacology (medical) Aphrodisiac lcsh:Miscellaneous systems and treatments Pharmacology Creatinine Traditional medicine Triglyceride biology business.industry lcsh:RM1-950 lcsh:RZ409.7-999 medicine.disease Streptozotocin biology.organism_classification cinnabar gold lcsh:Therapeutics. Pharmacology 030104 developmental biology Complementary and alternative medicine chemistry Hemoglobin mercury sulfide Shadguna Balijarita Makaradhwaja business medicine.drug Research Article |
| Zdroj: | Journal of Intercultural Ethnopharmacology Journal of Intercultural Ethnopharmacology, Vol 5, Iss 2, Pp 162-167 (2016) |
| ISSN: | 2146-8397 |
| Popis: | Background: Makaradhwaja a gold containing mercurial preparation used for diabetes mellitus in indigenous system of medicine. It is a popular aphrodisiac and rejuvenator traditional medicine. It is prepared by using processed gold, mercury and sulfur in different ratios by applying intermittent heating pattern in Valuka Yantra. Objectives: The aim of the study was to evaluate anti-diabetic effect of Shadguna Balijarita Makaradhwaja (SBM) on streptozotocin (STZ) induced diabetic rats. Materials and Methods: Diabetes was induced to normal rats by injecting STZ in dose 40 mg/kg. Powdered SBM and dried extract of Tinospora cordifolia were mixed with honey and administered orally for 20 days at dose 2.63 mg/kg and 42.34 mg/kg body weight, respectively. The effects of treatment on body weight changes and blood glucose levels were quantified on day 1, 5, 10, 15 and 21 of the experiments. On the 21st day, animals were sacrificed and gross histopathological changes in liver, kidney and pancreas were illustrated. Blood sugar level, glyacated hemoglobin, blood urea, serum cholesterol, serum creatinine, serum triglyceride and serum protein were estimated with standard methods. The study was conducted in the year 2011. Results: Test drug observed significant decrease (P < 0.001) in glyacated hemoglobin level compared to diabetic control rats. Blood sugar level of test drug group shown a significant decrease (279.11 ± 57.95) compared with diabetic rats. Conclusion: The present study demonstrates that SBM and dried extract of T. cordifolia with honey significantly reduces the blood glucose level and shows anti-diabetic effect. |
| Databáze: | OpenAIRE |
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