Risk assessment based on urinary bisphenol A levels in the general Korean population
| Autor: | Kwang-Soo Lee, Min-Ki Shin, Jin-Hyang Suh, Young-Ho Kho, Guiim Moon, Ahra Ko, Myung-Sil Hwang, In-Gyun Hwang, Jae-Hong Park, Jung-Mi Lee, Hui-Seung Kang, Hee-Seok Lee, Da-Hyun Jeong |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Tolerable daily intake endocrine system Adolescent Urinary system Food Contamination Urine Endocrine Disruptors 010501 environmental sciences Breast milk Risk Assessment 01 natural sciences Biochemistry Toxicology Young Adult 03 medical and health sciences chemistry.chemical_compound Animal science Phenols Plasticizers Republic of Korea Humans Medicine Benzhydryl Compounds Child 0105 earth and related environmental sciences General Environmental Science Creatinine business.industry Infant Newborn Infant Middle Aged Food safety Diet 030104 developmental biology chemistry Child Preschool Environmental Pollutants Female business Reproductive toxicity Environmental Monitoring Food contaminant |
| Zdroj: | Environmental Research. 150:606-615 |
| ISSN: | 0013-9351 |
| DOI: | 10.1016/j.envres.2016.03.024 |
| Popis: | Bisphenol A (BPA) is a high-volume industrial chemical used in the global production of polycarbonate plastics and epoxy resins, which are used in food and drink containers, such as tableware (plates and mugs). Due to its broad applications, BPA has been detected in human blood, urine and breast milk as well as environmental substances, including water, indoor and outdoor air, and dust. Indeed, exposure to high concentrations of BPA can result in a variety of harmful effects, including reproductive toxicity, through a mechanism of endocrine disruption. Our comparison of reported BPA urinary concentrations among different countries revealed that exposures in Korea may be higher than those in other Asian countries and North America, but lower than or similar to those in European countries. The current study included a total of 2044 eligible subjects of all ages. The subjects were evenly divided between males and females (48.58% and 51.42%, respectively). The geometric mean (GM) of pre-adjusted (adjusted) urinary BPA concentrations was 1.83μg/L (2.01μg/g creatinine) for subjects of all ages, and there was no statistically difference in BPA concentrations between males (1.90μg/L, 1.87μg/g creatinine) and females (1.76μg/L, 2.16μg/g creatinine). Multiple regression analysis revealed only one positive association between creatinine pre-adjusted urinary BPA concentration and age (β=-0.0868, p |
| Databáze: | OpenAIRE |
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