Autor: |
Yunhe Li, Qian Xia, Chunrong Zhu, Weidong Cao, Zhiyang Xia, Xinxin Liu, Bin Xiao, Keyu Chen, Yun Liu, Lei Zhong, Bangxian Tan, Jun Lei, Jiang Zhu |
Rok vydání: |
2022 |
Předmět: |
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Zdroj: |
Journal of inorganic biochemistry. 236 |
ISSN: |
1873-3344 |
Popis: |
Myeloperoxidase (MPO), a hallmark of the function and activation of innate immune cells, can act as a 'double-edged sword', contributing to clear infection as well as causing tissue oxidizing damage in various inflammatory diseases. In this study, an activatable Mn(II) chelate-based magnetic resonance imaging (MRI) contrast agent (CA), Mn-TyEDTA (TyEDTA = tyrosine derived ethylenediaminetetraacetic acid) structurally featuring a phenol group as the electron-donor, was developed to sense the activity of peroxidase in vitro and in vivo. Mn-TyEDTA demonstrated a peroxidase activity-dependent relaxivity in the presence of horseradish peroxidase (HRP)/H |
Databáze: |
OpenAIRE |
Externí odkaz: |
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