An activatable Mn(II) MRI probe for detecting peroxidase activity in vitro and in vivo

Autor:	Yunhe Li, Qian Xia, Chunrong Zhu, Weidong Cao, Zhiyang Xia, Xinxin Liu, Bin Xiao, Keyu Chen, Yun Liu, Lei Zhong, Bangxian Tan, Jun Lei, Jiang Zhu
Rok vydání:	2022
Předmět:	Gadolinium DTPA Manganese Contrast Media Water Hydrogen Peroxide Biochemistry Magnetic Resonance Imaging Uric Acid Inorganic Chemistry Mice Phenols Animals Tyrosine Protons Edetic Acid Horseradish Peroxidase Peroxidase
Zdroj:	Journal of inorganic biochemistry. 236
ISSN:	1873-3344
Popis:	Myeloperoxidase (MPO), a hallmark of the function and activation of innate immune cells, can act as a 'double-edged sword', contributing to clear infection as well as causing tissue oxidizing damage in various inflammatory diseases. In this study, an activatable Mn(II) chelate-based magnetic resonance imaging (MRI) contrast agent (CA), Mn-TyEDTA (TyEDTA = tyrosine derived ethylenediaminetetraacetic acid) structurally featuring a phenol group as the electron-donor, was developed to sense the activity of peroxidase in vitro and in vivo. Mn-TyEDTA demonstrated a peroxidase activity-dependent relaxivity in the presence of horseradish peroxidase (HRP)/H
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::494460021a4b37841bb8f61d607db614 https://pubmed.ncbi.nlm.nih.gov/36087435 Zobrazit plný text záznamu Full Text from ScienceDirect