A new role for the ginsenoside RG3 in antiaging via mitochondria function in ultraviolet-irradiated human dermal fibroblasts
| Autor: | Jisoo Park, Jongsun Park, Youngeun Hong, So Hee Kwon, Sungjin Park, Hyunji Lee, Chaeyeong Kim, Minhee Kim, Hyeonjeong Cho, Quangdon Tran |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cell growth Mitochondrion Biochemistry Genetics and Molecular Biology (miscellaneous) Adenosine Cell biology lcsh:QK1-989 Extracellular matrix Heme oxygenase Dermal fibroblast 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology 0302 clinical medicine Complementary and alternative medicine chemistry Apoptosis 030220 oncology & carcinogenesis lcsh:Botany medicine Adenosine triphosphate Biotechnology medicine.drug Research Article |
| Zdroj: | Journal of Ginseng Research, Vol 43, Iss 3, Pp 431-441 (2019) |
| ISSN: | 1226-8453 |
| Popis: | Background: The efficacy of ginseng, the representative product of Korea, and its chemical effects have been well investigated. The ginsenoside RG3 has been reported to exhibit apoptotic, anticancer, and antidepressant-like effects. Methods: In this report, the putative effect of RG3 on several cellular function including cell survival, differentiation, development and aging process were evaluated by monitoring each specific marker. Also, mitochondrial morphology and function were investigated in ultraviolet (UV)-irradiated normal human dermal fibroblast cells. Results: RG3 treatment increased the expression of extracellular matrix proteins, growth-associated immediate-early genes, and cell proliferation genes in UV-irradiated normal human dermal fibroblast cells. And, RG3 also resulted in enhanced expression of antioxidant proteins such as nuclear factor erythroid 2–related factor-2 and heme oxygenase-1. In addition, RG3 affects the morphology of UV-induced mitochondria and plays a role in protecting mitochondrial dysfunction. Conclusioin: RG3 restores mitochondrial adenosine triphosphate (ATP) and membrane potential via its antioxidant effects in skin cells damaged by UV irradiation, leading to an increase in proteins linked with the extracellular matrix, cell proliferation, and antioxidant activity. Keywords: Antiaging, Mitochondrial ATP, Normal Human Dermal Fibroblast cells, RG3, UV irradiation |
| Databáze: | OpenAIRE |
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