Siah Regulation of Pard3A Controls Neuronal Cell Adhesion During Germinal Zone Exit
| Autor: | Yiai Tong, Niraj Trivedi, Danielle Howell, David J. Solecki, Jakub K. Famulski, Richard J. Gilbertson, Yuan Yang |
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| Rok vydání: | 2010 |
| Předmět: |
Cerebellum
Ubiquitin-Protein Ligases Morphogenesis Synaptogenesis Immunoglobulins Cell Cycle Proteins Transfection Cell Line Mice Dogs Cell Movement Cell polarity Cell Adhesion medicine Animals Humans Protein Interaction Domains and Motifs Cell adhesion Adaptor Proteins Signal Transducing Neurons Multidisciplinary biology Cell adhesion molecule Stem Cells Ubiquitination Cell Polarity Protein Structure Tertiary Cell biology Ubiquitin ligase medicine.anatomical_structure biology.protein RNA Interference Signal transduction Cell Adhesion Molecules Protein Binding Signal Transduction |
| Zdroj: | Science. 330:1834-1838 |
| ISSN: | 1095-9203 0036-8075 |
| Popis: | Exiting the Birthplace In the developing mammalian brain, new neurons are not always born where they are needed. In order for immature neurons of the mouse cerebellum to leave their birthplace in the germinal zone and find their functional niche in the brain, the neurons need to migrate. Famulski et al. (p. 1834 , published online 25 November; see the Perspective by Métin and Luccardini ) now show that ubiquitin-mediated protein degradation regulates development of specific cell adhesions that the neurons need in order to exit their birthplace en route to their final functional location. |
| Databáze: | OpenAIRE |
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