DSCAM-AS1 up-regulation in invasive ductal carcinoma of breast and assessment of its potential as a diagnostic biomarker

Autor:	Vahid Kholghi Oskooei, Hamid Reza Khorshidi, Mohammad Taheri, Iman Azari, Soudeh Ghafouri-Fard
Rok vydání:	2019
Předmět:	Adult 0301 basic medicine Oncology Cancer Research medicine.medical_specialty animal structures Real-Time Polymerase Chain Reaction Pathogenesis 03 medical and health sciences DSCAM 0302 clinical medicine Breast cancer Downregulation and upregulation Internal medicine Biomarkers Tumor medicine Humans Diagnostic biomarker skin and connective tissue diseases Genetic Association Studies Aged Aged 80 and over business.industry Carcinoma Ductal Breast General Medicine Middle Aged Invasive ductal carcinoma medicine.disease Fold change Up-Regulation Gene Expression Regulation Neoplastic Tamoxifen 030104 developmental biology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Biomarker (medicine) Female RNA Long Noncoding business
Zdroj:	Breast Disease. 38:25-30
ISSN:	1558-1551 0888-6008
DOI:	10.3233/bd-180351
Popis:	The long non-coding RNA (lncRNA) DSCAM-AS1 has been demonstrated to participate in the pathogenesis of breast cancer and tamoxifen resistance. OBJECTIVE: To evaluate expression profile of DSCAM-AS1 in invasive ductal carcinoma of breast and its suitability as a biomarker for diagnosis of breast cancer. METHODS: We evaluated expression of DSCAM-AS1 in 108 breast tissues including tumoral and adjacent non-cancerous tissues (ANCTs) by means of quantitative real time PCR. RESULTS: DSCAM-AS1 was up-regulated in tumoral tissues compared with ANCTs (Fold change = 2.86, P = 0.011). Its expression was significantly higher in patients aged less than 55 compared with older patients (P = 0.02). However, its expression levels had not a good performance as a diagnostic biomarker for breast cancer. CONCLUSIONS: The significant up-regulation of DSCAM-AS1 in tumoral tissues compared with ANCTs provides further evidences for participation of this lncRNA in the pathogenesis of breast cancer. © 2019 - IOS Press and the authors. All rights reserved.
Databáze:	OpenAIRE
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