Surfactant protein D in atopic dermatitis and psoriasis
| Autor: | Hans Lomholt, Jens Madsen, Torben Steiniche, Kristian Otkjaer, Ole Haagen Nielsen, Uffe Holmskov, Christian Vestergaard, Thomas Hohwy, Gritt Søerensen |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Allergy Adolescent Enzyme-Linked Immunosorbent Assay Human skin Dermatology Skin infection Polymerase Chain Reaction Biochemistry Dermatitis Atopic Atopy Psoriasis medicine Humans Stratum spinosum Molecular Biology Aged integumentary system business.industry Atopic dermatitis Middle Aged Pulmonary Surfactant-Associated Protein D medicine.disease Immunohistochemistry medicine.anatomical_structure Case-Control Studies Immunology Female business Stratum basale |
| Zdroj: | University of Southern Denmark Hohwy, T, Otkjaer, K, Madsen, J, Søerensen, G, Vestergaard, C, Steiniche, T, Holmskov, U, Lomholt, H & Nielsen, O 2006, ' Surfactant protein D in atopic dermatitis and psoriasis ', Experimental Dermatology, vol. 15, no. 3, pp. 168-74 . https://doi.org/10.1111/j.1600-0625.2006.00406.x Hohwy, T, Otkjaer, K, Madsen, J, Sørensen, G L, Nielsen, O, Vestergaard, C, Steiniche, T, Holmskov, U & Lomholt, H 2006, ' Surfactant protein D in atopic dermatitis and psoriasis ', Experimental Dermatology, vol. 15, no. 3, pp. 168-174 . |
| ISSN: | 1600-0625 0906-6705 |
| DOI: | 10.1111/j.1600-0625.2006.00406.x |
| Popis: | Udgivelsesdato: marts 2006 The collectin surfactant protein-D (SP-D) shows antimicrobial and immuno-regulatory properties and has recently been detected in the basal layers of normal human skin. This molecule potentially plays an important role in inflammatory skin diseases and therefore SP-D content and location was examined using immunohistochemistry on skin biopsies from patients with the two major dermatologic diseases, psoriasis and atopic dermatitis. SP-D was located in the stratum basale of all biopsies with similar intense staining in both diseased and normal skin. Differences were detected in stratum spinosum where involved psoriatic skin showed intense staining through the entire region significantly different from uninvolved and normal skin. Lesional atopic skin showed moderate staining extending through the basal three-fourths of stratum spinosum. Using real time polymerase chain reaction analysis, no substantial up-regulation of SP-D mRNA was detected in lesional psoriatic skin, and a comparison of serum levels of SP-D between patients with atopic dermatitis or psoriasis and a group of age matched healthy controls did not show significant differences. In conclusion SP-D was significantly more abundant in the stratum spinosum of lesional psoriatic and atopic skin due to more cells producing the molecule rather than up-regulation of production in single cells of diseased skin. Further studies are needed to show if SP-D plays a role in the protection against skin infections or modulation of the inflammatory process in these common skin diseases. |
| Databáze: | OpenAIRE |
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