Rapid eye movement sleep promotes cortical plasticity in the developing brain
| Autor: | Marcos G. Frank, Leslie Renouard, Tammi Coleman, Julie Seibt, Sara J. Aton, Michelle C. Dumoulin Bridi |
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| Rok vydání: | 2015 |
| Předmět: |
genetic structures
Rapid eye movement sleep Biology Ocular dominance Synapse 03 medical and health sciences 0302 clinical medicine synapse Neuroplasticity sleep Neuroscience of sleep Research Articles 030304 developmental biology 0303 health sciences function Multidisciplinary SciAdv r-articles Sleep in non-human animals eye diseases Monocular deprivation plasticity Ontogeny Developmental plasticity sense organs Neuroscience 030217 neurology & neurosurgery Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | Rapid eye movement sleep plays a critical role in shaping developing circuits in the cerebral cortex. Rapid eye movement sleep is maximal during early life, but its function in the developing brain is unknown. We investigated the role of rapid eye movement sleep in a canonical model of developmental plasticity in vivo (ocular dominance plasticity in the cat) induced by monocular deprivation. Preventing rapid eye movement sleep after monocular deprivation reduced ocular dominance plasticity and inhibited activation of a kinase critical for this plasticity (extracellular signal–regulated kinase). Chronic single-neuron recording in freely behaving cats further revealed that cortical activity during rapid eye movement sleep resembled activity present during monocular deprivation. This corresponded to times of maximal extracellular signal–regulated kinase activation. These findings indicate that rapid eye movement sleep promotes molecular and network adaptations that consolidate waking experience in the developing brain. |
| Databáze: | OpenAIRE |
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