Squamins C–F, four cyclopeptides from the seeds of Annona globiflora
| Autor: | Francisco Cen-Pacheco, Cristina Cuadrado, Vanihamin Domínguez-Melendez, Javier Sosa-Rueda, Araceli Ortiz-Celiseo, Fernando C. López-Fentanes, Antonio Hernández Daranas, José J. Fernández |
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| Přispěvatelé: | Gobierno del Estado de Veracruz de Ignacio de la Llave, Ministerio de Ciencia e Innovación (España), Centro de Supercomputación de Galicia, CSIC - Secretaría General Adjunta de Informática (SGAI), Cabildo de Tenerife |
| Rok vydání: | 2022 |
| Předmět: |
Phytochemicals
Annonaceae Plant Science Horticulture Cyclopeptides Peptides Cyclic Biochemistry Annona HeLa Cervical carcinoma medicine Humans Cytotoxic T cell Amino Acid Sequence Molecular Biology Peptide sequence Cytotoxic activity biology Chemistry Cancer General Medicine biology.organism_classification medicine.disease Antineoplastic Agents Phytogenic Cell culture Seeds Annona globiflora Schltdl HeLa Cells |
| Zdroj: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2021.112839 |
| Popis: | Four cyclic octapeptides, squamins C–F, were isolated from the seeds of Annona globiflora Schltdl. These compounds share part of their amino acid sequence, -Pro-Met(O)-Tyr-Gly-Thr-, with previously reported squamins A and B. Their structures were determined using NMR spectroscopic techniques together with quantum mechanical calculations (QM-NMR), ESI-HRMS data and a modified version of Marfey's chromatographic method. All compounds showed cytotoxic activity against DU-145 (human prostate cancer) and HeLa (human cervical carcinoma) cell lines. Clearly, A. globiflora is an important source of bioactive molecules, which could promote the sustainable exploitation of this undervalued specie. This work was supported by the Government of the State of Veracruz de Ignacio de la Llave, Veracruz Council for Scientific Research and Technological Development [COVEICyDET, grant number 14 1953/2021], and by the Spanish Ministry of Science and Innovation (PID2019-109476RB-C21). This study made use of the CESGA and SGAI-CSIC supercomputing facilities. We thank G. Jones for English text edition, funded by Cabildo de Tenerife, TFinnova Program supported by MEDI and FDCAN. |
| Databáze: | OpenAIRE |
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