Acceptive Immunity: The Role of Fucosylated Glycans in Human Host–Microbiome Interactions

Autor: Svetlana Kononova, Ekaterina A. Litvinova, Maria Skalinskaya, Timur Vakhitov, Stanislav Sitkin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
0301 basic medicine
intestinal microbiota
immune tolerance
Glycosylation
Review
Fucose
Immune tolerance
fucosylated glycans
lcsh:Chemistry
chemistry.chemical_compound
fucose
Cell Wall
Intestinal Mucosa
lcsh:QH301-705.5
Spectroscopy
biology
Microbiota
Age Factors
General Medicine
host–microbiome interactions
Computer Science Applications
Cell biology
Host-Pathogen Interactions
medicine.symptom
Antibody
Bacterial Outer Membrane Proteins
030106 microbiology
Immunoglobulins
Inflammation
acceptive immunity
Catalysis
Inorganic Chemistry
03 medical and health sciences
Immune system
Polysaccharides
Immunity
medicine
Animals
Humans
Microbiome
Physical and Theoretical Chemistry
Molecular Biology
Antigens
Bacterial
Organic Chemistry
Mucin
biochemical phenomena
metabolism
and nutrition
Gastrointestinal Microbiome
030104 developmental biology
chemistry
lcsh:Biology (General)
lcsh:QD1-999
Immune System
biology.protein
Zdroj: International Journal of Molecular Sciences, Vol 22, Iss 3854, p 3854 (2021)
International Journal of Molecular Sciences
ISSN: 1661-6596
1422-0067
Popis: The growth in the number of chronic non-communicable diseases in the second half of the past century and in the first two decades of the new century is largely due to the disruption of the relationship between the human body and its symbiotic microbiota, and not pathogens. The interaction of the human immune system with symbionts is not accompanied by inflammation, but is a physiological norm. This is achieved via microbiota control by the immune system through a complex balance of pro-inflammatory and suppressive responses, and only a disturbance of this balance can trigger pathophysiological mechanisms. This review discusses the establishment of homeostatic relationships during immune system development and intestinal bacterial colonization through the interaction of milk glycans, mucins, and secretory immunoglobulins. In particular, the role of fucose and fucosylated glycans in the mechanism of interactions between host epithelial and immune cells is discussed.
Databáze: OpenAIRE
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