Second generation antihistamines in the treatment of seasonal allergic rhinitis due to Parietaria and cypress pollen
| Autor: | Luigi Macchia, Giulia De Michele, Alfonso Iudice, Maria F. Caiaffa, Roberto Di Paola, Alfredo Tursi, G. Bariletto |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Parietaria Side effect medicine.disease_cause law.invention Randomized controlled trial Double-Blind Method law Pollen medicine Humans Terfenadine Cypress Pharmacology biology business.industry Rhinitis Allergic Seasonal Allergens Astemizole biology.organism_classification Treatment Outcome Immunology Cypress pollen Histamine H1 Antagonists Female business medicine.drug |
| Zdroj: | Pharmacological research. 44(6) |
| ISSN: | 1043-6618 |
| Popis: | Second generation antihistamines have been employed in the treatment of seasonal allergic rhinitis for many years. However, their effects on two distinctive Mediterranean allergic conditions, viz. Parietaria pollinosis and cypress pollinosis, have been scarcely investigated, so far. A comparative efficacy and side effect trial of astemizole and terfenadine in the treatment of seasonal allergic rhinitis due to either Parietaria or cypress pollen was carried out in 27 adult patients, according to a double-blind, double-dummy parallel-group design. Airborne pollen monitoring allowed comparison of symptom scores with pollen counts. Seven patients (26%) withdrew, due to poor symptom control. In contrast, in a subset of 15 patients who completed the trial, treatment led to a substantial and statistically significant decline in symptom severity in both the astemizole and the terfenadine study group. However, no statistically significant inter-group differences could be detected. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect