Calcium and bicarbonate ions mediate the inhibition of mast cell histamine release by Avène spa water
| Autor: | Henri Cousse, Pascal Bordat, Eugène Neuzil, Francine Joly, Lysiane Galoppin |
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| Rok vydání: | 2001 |
| Předmět: |
Male
Bicarbonate chemistry.chemical_element Calcium Substance P Histamine Release chemistry.chemical_compound medicine Animals Pharmacology (medical) Mast Cells Rats Wistar Magnesium ion Edetic Acid Pharmacology Calcium metabolism Chemistry fungi Water Mast cell Rats EGTA Bicarbonates medicine.anatomical_structure Biochemistry Liberation Histamine |
| Zdroj: | Fundamentalclinical pharmacology. 14(6) |
| ISSN: | 0767-3981 |
| Popis: | Avene spa water (ASW) inhibits the histamine release induced in mast cells by substance P; the inhibition is reversed by EDTA and by EGTA. Calcium and magnesium ions, the major cations present in ASW, were experimented in simple saline solutions in the presence of various counter-ions. Only calcium salts inhibited the peptidergic stimulation, with different potencies ruled by the nature of the counter-anion (HCO3- > Cl- > SO4(2)). On a Ca2+ concentration basis, ASW was, however, more inhibitory, suggesting that other compounds present in ASW potentiate the effect of calcium. |
| Databáze: | OpenAIRE |
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