Abnormal Expression of Galactosyl(α1→3) Galactose Epitopes in Squamous Cells of the Uterine Cervix Infected by Human Papillomavirus
| Autor: | Gisela Cáceres-Dittmar, Dimas E Hernández, Félix J. Tapia, José L. Avila, Ivo W. Tremont-Lukats, Miguel Rojas |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Uterine Cervical Neoplasms Cervix Uteri Biology Disaccharides Cervical intraepithelial neoplasia Epithelium Epitope Pathology and Forensic Medicine Epitopes chemistry.chemical_compound medicine Humans Human papillomavirus Papillomaviridae Molecular Biology Gene Papillomavirus Infections virus diseases Cell Biology General Medicine Middle Aged Uterine Cervical Dysplasia medicine.disease Koilocyte Tumor Virus Infections Uterine cervix chemistry Galactose Carcinoma Squamous Cell Immunohistochemistry Female |
| Zdroj: | Pathobiology. 64:239-246 |
| ISSN: | 1423-0291 1015-2008 |
| DOI: | 10.1159/000164054 |
| Popis: | This study describes the presence of alpha-galactosyl epitopes on 12 cervical biopsy samples with features of human papillomavirus infection (HPV) and different stages of cervical intraepithelial neoplasia. An avidin-biotin-peroxidase assay with a monoclonal antibody recognizing gal(alpha 1--3)gal residues was strongly positive in 5 of 12 cases. None of the controls stained (p = 0.02). Immunostaining was intense in the areas with the highest viral load (koilocytes and keratinocytes) and absent in malignant foci. Immunostaining was also absent in normal exo- and endocervical epithelium of 12 controls with no features of HPV infection. A faint background staining in cases and controls was evident, but similar. These initial findings suggest that alpha-galactosyl epitopes are expressed in cervical squamous cells infected with HPV, turning them vulnerable to lysis by natural anti-alpha-galactosyl antibodies. |
| Databáze: | OpenAIRE |
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