The Role of Nrf2 in Cellular Innate Immune Response to Inflammatory Injury
| Autor: | Young-Joon Surh, Jiyoung Kim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Innate immunity
Inflammation Chemokine education.field_of_study Cell signaling Innate immune system biology Health Toxicology and Mutagenesis Population Innate lymphoid cell respiratory system Toxicology environment and public health Nrf2 Cell biology Proinflammatory cytokine Perspectives - Minireview Cellular stress response Immunology biology.protein medicine medicine.symptom education |
| Zdroj: | Toxicological Research |
| ISSN: | 1976-8257 |
| DOI: | 10.5487/tr.2009.25.4.159 |
| Popis: | Nuclear factor erythroid derived 2-related factor-2 (Nrf2) is a master transcription regulator of antioxidant and cytoprotective proteins that mediate cellular defense against oxidative and inflammatory stresses. Disruption of cellular stress response by Nrf2 deficiency causes enhanced susceptibility to infection and related inflammatory diseases as a consequence of exacerbated immuneediated hypersensitivity and autoimmunity. The cellular defense capacity potentiated by Nrf2 activation appears to balance the population of CD4+ and CD8+ of lymph node cells for proper innate immune responses. Nrf2 can negatively regulate the activation of pro-inflammatory signaling molecules such as p38 MAPK, NF-KB, and AP-1. Nrf2 subsequently functions to inhibit the production of pro-inflammatory mediators including cytokines, chemokines, cell adhesion molecules, matrix metalloprotein-ases, COX-2 and iNOS. Although not clearly elucidated, the antioxidative function of genes targeted by Nrf2 may cooperatively regulate the innate immune response and also repress the expression of proinflammatory mediators. |
| Databáze: | OpenAIRE |
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