Oral pre-treatment with epigallocatechin gallate in 6-OHDA lesioned rats produces subtle symptomatic relief but not neuroprotection
| Autor: | Michael Kassiou, Katherine R. Leaver, Jasmine M. Henderson, Nathan J. Creber, Haydn N. Allbutt |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Dyskinesia Drug-Induced Parkinson's disease Rotation Dopamine Posture Administration Oral Cell Count Epigallocatechin gallate Pharmacology Motor Activity Neuropsychological Tests medicine.disease_cause Neuroprotection Antioxidants Catechin Rats Sprague-Dawley chemistry.chemical_compound Adrenergic Agents medicine Animals Oxidopamine Neurons business.industry General Neuroscience Parkinsonism Neurodegeneration Dopaminergic medicine.disease Symptomatic relief Immunohistochemistry Surgery Rats Substantia Nigra chemistry Female business Oxidative stress |
| Zdroj: | Brain research bulletin. 80(6) |
| ISSN: | 1873-2747 |
| Popis: | Much recent work is investigating the role of oxidative stress and inflammatory mechanisms in the aetiology of neurodegeneration in Parkinson's disease. The present study evaluated whether the green tea constituent epigallocatechin gallate (EGCG) which has both anti-oxidant and anti-inflammatory properties, exerts neuroprotection and symptomatic effects when administered orally as a pre-treatment prior to 6-hydroxydopamine (6-OHDA) lesions. Groups of rats were given either 1mg/kg, 2mg/kg EGCG or vehicle solution for 14 days. Sham or 6-OHDA surgery was performed on day 11 of the drug administration protocol. Behavioural analysis was conducted before drugs/vehicle solution, again during the treatment period and then repeated at fortnightly intervals for 2 months post-operatively. Whilst some subtle behavioural improvements in postural abnormalities and ability to cross a narrow beam were observed in lesioned rats after EGCG (vs. vehicle) there was no evidence of neuroprotection on post-mortem quantification of degree of nigral dopaminergic neuronal loss when comparing the lesioned groups given the various treatments. |
| Databáze: | OpenAIRE |
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