Brain methionine- and leucine-enkephalin receptors in patients with dementia
| Autor: | Leo Paljärvi, Juha O. Rinne, P. Lönnberg, Päivi Marjamäki, P. K. Mölsä, Erkki Säkö |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Met-enkephalin
endocrine system medicine.medical_specialty Enkephalin Hippocampus δ-opioid receptor chemistry.chemical_compound Limbic system Alzheimer Disease Internal medicine medicine Humans Opioid peptide Aged Temporal cortex Aged 80 and over musculoskeletal neural and ocular physiology General Neuroscience Dementia Vascular Brain Leu-enkephalin nervous system diseases Endocrinology medicine.anatomical_structure nervous system chemistry Receptors Opioid hormones hormone substitutes and hormone antagonists Enkephalin Leucine |
| Zdroj: | Neuroscience letters. 161(1) |
| ISSN: | 0304-3940 |
| Popis: | Brain [3H]Met- and [3H]Leu-enkephalin binding was studied in patients with Alzheimer's disease (AD) and vascular dementia (VD), and in age-matched controls. Brain areas investigated were the internal and external globus pallidus, amygdala, hippocampus and temporal cortex. In AD, the binding of both enkephalins decreased in all brain areas examined, except in the external globus pallidus for both enkephalins and in the internal globus pallidus for leucine-enkephalin. Scatchard analysis of amygdaloid samples showed a decrease in the number of receptors (Bmax) without any change in their affinity (Kd). In patients with VD, no significant changes in enkephalin binding were seen. Thus, in AD, enkephalin binding (mainly reflecting delta opioid receptor subtype) is decreased, especially in limbic areas. |
| Databáze: | OpenAIRE |
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