The hepato-protective effect of eupatilin on an alcoholic liver disease model of rats
| Autor: | Jaehwi Lee, Uy Dong Sohn, Hak Yeong Lee, Won Seok Choi, Tae Wook Kim, Yoonjin Nam |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Alcoholic liver disease Antioxidant Physiology medicine.medical_treatment Eupatilin Pharmacology medicine.disease_cause Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Liver injury Inflammation biology Ethanol business.industry Glutathione medicine.disease Malondialdehyde 030104 developmental biology chemistry Oxidative stress biology.protein Original Article business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology |
| ISSN: | 1226-4512 |
| Popis: | Eupatilin is known to possess anti-apoptotic, anti-oxidative, and anti-inflammatory properties. We report here that eupatilin has a protective effect on the ethanol-induced injury in rats. Sprague–Dawley rats were divided into 6 groups: control, vehicle, silymarin, eupatilin 10 mg/kg, eupatilin 30 mg/kg, and eupatilin 100 mg/kg. Plasma levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were analyzed to determine the extent of liver damage. Total cholesterol (TC) and triglycerides (TG) were analyzed to determine the level of liver steatosis. Malondialdehyde level, superoxide dismutase (SOD) activity, and glutathione (GSH) level were analyzed to determine the extent of oxidative stress. Tumor necrosis factor (TNF)-α and interleukin (IL)-1β were quantified to verify the degree of inflammation. Based on our findings, chronic alcohol treatment significantly changed the serum indexes and liver indicators of the model rats, which were significantly improved by eupatilin treatment. Rats in the eupatilin-treatment group showed reduced levels of AST, ALT, TG, TC, TNF-α, and IL-1β, increased SOD activity and GSH levels, and improved overall physiology compared to the alcoholic liver disease model rats. H&E staining also verified the eupatilin-mediated improvement in liver injury. In conclusion, eupatilin inhibits alcohol-induced liver injury via its antioxidant and anti-inflammatory effects. |
| Databáze: | OpenAIRE |
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