Central nervous system involvement in Rosai-Dorfman disease: Report of a case with a review of the literature
| Autor: | Shanop Shuangshoti, Churaiorn Unhasuta, Sanya Sukpanichnant, Yot Navalitloha, Samruay Shuangshoti |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry CD68 Central nervous system General Medicine medicine.disease Plasma cell granuloma Pathology and Forensic Medicine Emperipolesis Meningioma medicine.anatomical_structure Langerhans cell histiocytosis Medicine Neurology (clinical) business Histiocyte Rosai–Dorfman disease |
| Zdroj: | Neuropathology. 19:341-346 |
| ISSN: | 1440-1789 0919-6544 |
| Popis: | A 55-year-old woman had Rosai-Dorfman disease (RDD) forming multiple masses of abnormal histiocytes, three in the cranial cavity and one in the left orbit that was proptotic. The masses were removed and found to consist of abnormal histiocytes that were immunoreactive to cluster designation 68 (CD68) (KP-1), alpha-1-antitrypsin and S-100 protein and showed emperipolesis. A review of 28 cases of RDD, including this instance, revealed a ratio of 5:2 between males and females and a mean age of 32 years. Intracranial involvement was much more frequent than that of the spinal cord. Histologically, central nervous system (CNS) RDD must be distinguished from meningioma, Langerhans cell histiocytosis, and plasma cell granuloma. Surgical extirpation appears to be the treatment of choice for this idiopathic histiocytic proliferative disorder of the CNS in comparison with radiotherapy and steroid treatment, which have also been tried. |
| Databáze: | OpenAIRE |
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