Pericardial Rather Than Epicardial Fat is a Cardiometabolic Risk Marker: An MRI vs Echo Study
| Autor: | F. Frassi, Anna Maria Sironi, Vincenzo Positano, Daniele De Marchi, Eugenio Picano, Massimo Lombardi, Vladislav Chubuchny, Rosa Sicari, R. Petz, Amalia Gastaldelli |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Waist medicine.medical_treatment Peri Magnetic Resonance Imaging Cine Adipose tissue Sensitivity and Specificity Body Mass Index Risk Factors Internal medicine Humans Medicine Radiology Nuclear Medicine and imaging Aged medicine.diagnostic_test business.industry Insulin Magnetic resonance imaging Middle Aged Prognosis medicine.disease Radiography Blood pressure Adipose Tissue Cardiovascular Diseases Echocardiography Cardiology Female Metabolic syndrome Cardiology and Cardiovascular Medicine business Pericardium Body mass index Follow-Up Studies |
| Zdroj: | Journal of the American Society of Echocardiography. 24:1156-1162 |
| ISSN: | 0894-7317 |
| DOI: | 10.1016/j.echo.2011.06.013 |
| Popis: | Background Several studies using echocardiography identified epicardial adipose tissue (EPI) as an important cardiometabolic risk marker. However, validation compared with magnetic resonance imaging (MRI) or computed tomography has not been performed. Moreover, pericardial adipose tissue (PERI) has recently been shown to have some correlation with cardiovascular disease risk factors. The aims of this study were to validate echocardiographic analyses compared with MRI and to evaluate which cardiac fat depot (EPI or PERI) is the most appropriate cardiovascular risk marker. Methods Forty-nine healthy subjects were studied (age range, 25–68 years; body mass index, 21–40 kg/m 2 ), and PERI and EPI fat depots were measured using echocardiography and MRI. Findings were correlated with MRI visceral fat and subcutaneous fat, blood pressure, insulin sensitivity, triglycerides, cholesterol, insulin, glucose, and 10-year coronary heart disease risk. Results Most cardiac fat was constituted by PERI (about 77%). PERI thickness by echocardiography was well correlated with MRI area ( r = 0.36, P = .009), and independently of the technique used for quantification, PERI was correlated with body mass index, waist circumference, visceral fat, subcutaneous fat, blood pressure, insulin sensitivity, triglycerides, cholesterol, glucose, and coronary heart disease risk. On the contrary, EPI thicknesses correlated only with age did not correlate significantly with MRI EPI areas, which were found to correlate with age, body mass index, subcutaneous fat, and hip and waist circumferences. Conclusions Increased cardiac fat in the pericardial area is strongly associated with features of the metabolic syndrome, whereas no correlation was found with EPI, indicating that in clinical practice, PERI is a better cardiometabolic risk marker than EPI. |
| Databáze: | OpenAIRE |
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