Outer Membrane Protein‐Coated Nanoparticles as Antibacterial Vaccine Candidates
| Autor: | Ahmad Raza, Muhammad Irfan Anwar, M. I. Anwar, Bushra Akhtar, Faqir Muhammad, Abdul Aleem |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_treatment
Nanoparticle Bioengineering 01 natural sciences Biochemistry Article Analytical Chemistry Immune system Immunity Drug Discovery medicine biology 010405 organic chemistry Chemistry Membrane coating Biomimetic nanoparticles biology.organism_classification 0104 chemical sciences Outer membrane Membrane Nanoformulation Biophysics Molecular Medicine Bacterial outer membrane Adjuvant Bacteria |
| Zdroj: | International Journal of Peptide Research and Therapeutics |
| ISSN: | 1573-3904 1573-3149 |
| Popis: | Nanoformulations are novel therapeutic strategies as compared to traditional treatments. The development of biomimetic nanoparticles by combining the natural cellular material with synthetic nanoparticles has inspired innovative vaccine strategies for modifying the antibacterial immunity. A lot of work has been done in which synthetic nanoparticles are coated with biomimetic cellular membranes for enhancement of biological functions and treatments. Outer membrane protein of bacteria not only act as adjuvant but also contain a large number of immunogenic antigens that play an important role in motivating the native immunity and stimulating the immune responses of the body. Outer membrane protein coating onto the surfaces of synthetic nanoparticles has synergistic effects to produce antibacterial responses. This article reviews the recent improvements related to the bacterial membrane-coated nanoparticles for antibacterial immunization. |
| Databáze: | OpenAIRE |
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