Fecal Enterobacteriales enrichment is associated with increased in vivo intestinal permeability in humans

Autor: Patrice D. Cani, Edith Gallagher, Umer Zeeshan Ijaz, Richard J. Ellis, P.J. Hinton, David Russell-Jones, Camilla Pedersen, Felicity Horton, M. Denise Robertson, Roberto M. La Ragione, Thibaut Duparc, Etana Jaiyeola
Přispěvatelé: UCL - SSS/LDRI - Louvain Drug Research Institute
Rok vydání: 2018
Předmět:
intestinal microbiota
Blood Glucose
Male
0301 basic medicine
Enterobacteriales
medicine.medical_specialty
endocrine system diseases
Physiology
030209 endocrinology & metabolism
Type 2 diabetes
Permeability
Feces
03 medical and health sciences
0302 clinical medicine
Enterobacteriaceae
In vivo
Physiology (medical)
Internal medicine
Diabetes mellitus
medicine
Humans
Clinical significance
Original Research
glucose control
2. Zero hunger
chemistry.chemical_classification
Intestinal permeability
biology
intestinal permeability
business.industry
nutritional and metabolic diseases
Fatty acid
Middle Aged
medicine.disease
biology.organism_classification
Endotoxemia
Gastrointestinal Microbiome
3. Good health
Intestines
030104 developmental biology
Endocrinology
Diabetes Mellitus
Type 2
chemistry
Case-Control Studies
type 2 diabetes
Insulin Resistance
business
Zdroj: Physiological Reports
Physiological Reports, Vol. 6, no.7, p. e13649 [1-17] (2018)
ISSN: 2051-817X
DOI: 10.14814/phy2.13649
Popis: Type 2 diabetes (T2D) has been linked with increased intestinal permeability, but the clinical significance of this phenomenon is unknown. The objective of this study was to investigate the potential link between glucose control, intestinal permeability, diet and intestinal microbiota in patients with T2D. Thirty-two males with well-controlled T2D and 30 age-matched male controls without diabetes were enrolled in a case-control study. Metabolic parameters, inflammatory markers, endotoxaemia and intestinal microbiota in individuals subdivided into high (HP) and normal (LP) colonic permeability groups, were the main outcomes. In T2D, the HP group had significantly higher fasting glucose (P = 40 0.034) and plasma non-esterified fatty acid levels (P = 0.05) compared with the LP group. Increased colonic permeability was also linked with altered abundances of selected microbial taxa. The microbiota of both T2D and control HP groups was enriched with Enterobacteriales. In conclusion, high intestinal permeability was associated with poorer fasting glucose control in T2D patients and changes in some microbial taxa in both T2D patients and non-diabetic controls. Therefore, enrichment in the gram- negative order Enterobacteriales may characterise impaired colonic permeability prior to/independently from a disruption in glucose tolerance.
Databáze: OpenAIRE
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