Contributions of tissue-specific pathologies to corneal injuries following exposure to SM vapor
| Autor: | Tracey A. Hamilton, Marian R. Nelson, Megan E Lyman, Elliot J. Glotfelty, Patrick M. McNutt, Kaylie M. Tuznik |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Corneal endothelium Pathology medicine.medical_specialty genetic structures General Biochemistry Genetics and Molecular Biology Article Cornea 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine History and Philosophy of Science In vivo Mustard Gas medicine Animals Humans Limbal stem cell Corneal epithelium General Neuroscience Sulfur mustard Environmental exposure Environmental Exposure eye diseases Disease Models Animal 030104 developmental biology medicine.anatomical_structure chemistry 030221 ophthalmology & optometry sense organs Stem cell Volatilization Corneal Injuries |
| Popis: | Corneal injuries resulting from ocular exposure to sulfur mustard (SM) vapor are the most prevalent chemical warfare injury. Ocular exposures exhibit three distinct, dose-dependent clinical trajectories: complete injury resolution, immediate transition to a chronic injury, or apparent recovery followed by the subsequent development of persistent ocular manifestations. These latter two trajectories include a constellation of corneal symptoms that are collectively known as mustard gas keratopathy (MGK). The etiology of MGK is not understood. Here, we synthesize recent findings from in vivo rabbit SM vapor studies, suggesting that tissue-specific damage during the acute injury can decrement the regenerative capacities of corneal endothelium and limbal stem cells, thereby predisposing the cornea to the chronic or delayed forms of MGK. This hypothesis not only provides a mechanism to explain the acute and MGK injuries but also identifies novel therapeutic modalities to mitigate or eliminate the acute and long-term consequences of ocular exposure to SM vapor. |
| Databáze: | OpenAIRE |
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