The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users
Autor: | Anne Marije Kaag, Reinout W. Wiers, Anneke E. Goudriaan, Judith R. Homberg, G.A. van Wingen, Lianne Schmaal, Liesbeth Reneman, W. van den Brink, Jorien A. M. Jansen, Mieke H. J. Schulte |
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Přispěvatelé: | APH - Personalized Medicine, APH - Mental Health, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, Radiology and Nuclear Medicine, APH - Digital Health, Psychology Other Research (FMG), Ontwikkelingspsychologie (Psychologie, FMG), Erasmus MC other, Erasmus School of Law, Orthopedics and Sports Medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention |
Rok vydání: | 2018 |
Předmět: |
Male
Marijuana Abuse Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13] Physiology Toxicology Prefrontal cortex Drug Users Nicotine Tobacco Use 0302 clinical medicine Cocaine Alcohol tobacco Pharmacology (medical) Gray Matter Young adult VBM biology Organ Size Tobacco Use Disorder Middle Aged Magnetic Resonance Imaging Substance abuse Alcoholism Psychiatry and Mental health Polysubstance dependence Alcohol medicine.drug Adult Adolescent Alcohol Drinking Substance-Related Disorders Gray matter volume Neuroimaging Cocaine-Related Disorders Young Adult 03 medical and health sciences Tobacco medicine Humans Cannabis Pharmacology Ethanol business.industry Voxel-based morphometry medicine.disease biology.organism_classification 030227 psychiatry Self Report business 030217 neurology & neurosurgery |
Zdroj: | Drug and Alcohol Dependence Drug and alcohol dependence, 187, 186-194. Elsevier Ireland Ltd Drug and Alcohol Dependence, 187, 186-194. Elsevier Drug and Alcohol Dependence, 187, pp. 186-194 Drug and Alcohol Dependence, 187, 186-194 Kaag, A M, Schulte, M H J, Jansen, J M, van Wingen, G, Homberg, J, van den Brink, W, Wiers, R W, Schmaal, L, Goudriaan, A E & Reneman, L 2018, ' The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users ', Drug and Alcohol Dependence, vol. 187, pp. 186-194 . https://doi.org/10.1016/j.drugalcdep.2018.03.010 Drug and Alcohol Dependence, 187, 186-194. Elsevier Ireland Ltd |
ISSN: | 0376-8716 |
Popis: | Contains fulltext : 193278.pdf (Publisher’s version ) (Closed access) BACKGROUND: Neuroimaging studies have demonstrated gray matter (GM) volume abnormalities in substance users. While the majority of substance users are polysubstance users, very little is known about the relation between GM volume abnormalities and polysubstance use. METHODS: In this study we assessed the relation between GM volume, and the use of alcohol, tobacco, cocaine and cannabis as well as the total number of substances used, in a sample of 169 males: 15 non-substance users, 89 moderate drinkers, 27 moderate drinkers who also smoke tobacco, 13 moderate drinkers who also smoke tobacco and use cocaine, 10 heavy drinkers who smoke tobacco and use cocaine and 15 heavy drinkers who smoke tobacco, cannabis and use cocaine. RESULTS: Regression analyses showed that there was a negative relation between the number of substances used and volume of the dorsal medial prefrontal cortex (mPFC) and the ventral mPFC. Without controlling for the use of other substances, the volume of the dorsal mPFC was negatively associated with the use of alcohol, tobacco, and cocaine. After controlling for the use of other substances, a negative relation was found between tobacco and cocaine and volume of the thalami and ventrolateral PFC, respectively. CONCLUSION: These findings indicate that mPFC alterations may not be substance-specific, but rather related to the number of substances used, whereas, thalamic and ventrolateral PFC pathology is specifically associated with tobacco and cocaine use, respectively. These findings are important, as the differential alterations in GM volume may underlie different cognitive deficits associated with substance use disorders. |
Databáze: | OpenAIRE |
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