The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users

Autor: Anne Marije Kaag, Reinout W. Wiers, Anneke E. Goudriaan, Judith R. Homberg, G.A. van Wingen, Lianne Schmaal, Liesbeth Reneman, W. van den Brink, Jorien A. M. Jansen, Mieke H. J. Schulte
Přispěvatelé: APH - Personalized Medicine, APH - Mental Health, Adult Psychiatry, ANS - Compulsivity, Impulsivity & Attention, Radiology and Nuclear Medicine, APH - Digital Health, Psychology Other Research (FMG), Ontwikkelingspsychologie (Psychologie, FMG), Erasmus MC other, Erasmus School of Law, Orthopedics and Sports Medicine, Anatomy and neurosciences, Psychiatry, Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention
Rok vydání: 2018
Předmět:
Male
Marijuana Abuse
Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13]
Physiology
Toxicology
Prefrontal cortex
Drug Users
Nicotine
Tobacco Use
0302 clinical medicine
Cocaine
Alcohol tobacco
Pharmacology (medical)
Gray Matter
Young adult
VBM
biology
Organ Size
Tobacco Use Disorder
Middle Aged
Magnetic Resonance Imaging
Substance abuse
Alcoholism
Psychiatry and Mental health
Polysubstance dependence
Alcohol
medicine.drug
Adult
Adolescent
Alcohol Drinking
Substance-Related Disorders
Gray matter volume
Neuroimaging
Cocaine-Related Disorders
Young Adult
03 medical and health sciences
Tobacco
medicine
Humans
Cannabis
Pharmacology
Ethanol
business.industry
Voxel-based morphometry
medicine.disease
biology.organism_classification
030227 psychiatry
Self Report
business
030217 neurology & neurosurgery
Zdroj: Drug and Alcohol Dependence
Drug and alcohol dependence, 187, 186-194. Elsevier Ireland Ltd
Drug and Alcohol Dependence, 187, 186-194. Elsevier
Drug and Alcohol Dependence, 187, pp. 186-194
Drug and Alcohol Dependence, 187, 186-194
Kaag, A M, Schulte, M H J, Jansen, J M, van Wingen, G, Homberg, J, van den Brink, W, Wiers, R W, Schmaal, L, Goudriaan, A E & Reneman, L 2018, ' The relation between gray matter volume and the use of alcohol, tobacco, cocaine and cannabis in male polysubstance users ', Drug and Alcohol Dependence, vol. 187, pp. 186-194 . https://doi.org/10.1016/j.drugalcdep.2018.03.010
Drug and Alcohol Dependence, 187, 186-194. Elsevier Ireland Ltd
ISSN: 0376-8716
Popis: Contains fulltext : 193278.pdf (Publisher’s version ) (Closed access) BACKGROUND: Neuroimaging studies have demonstrated gray matter (GM) volume abnormalities in substance users. While the majority of substance users are polysubstance users, very little is known about the relation between GM volume abnormalities and polysubstance use. METHODS: In this study we assessed the relation between GM volume, and the use of alcohol, tobacco, cocaine and cannabis as well as the total number of substances used, in a sample of 169 males: 15 non-substance users, 89 moderate drinkers, 27 moderate drinkers who also smoke tobacco, 13 moderate drinkers who also smoke tobacco and use cocaine, 10 heavy drinkers who smoke tobacco and use cocaine and 15 heavy drinkers who smoke tobacco, cannabis and use cocaine. RESULTS: Regression analyses showed that there was a negative relation between the number of substances used and volume of the dorsal medial prefrontal cortex (mPFC) and the ventral mPFC. Without controlling for the use of other substances, the volume of the dorsal mPFC was negatively associated with the use of alcohol, tobacco, and cocaine. After controlling for the use of other substances, a negative relation was found between tobacco and cocaine and volume of the thalami and ventrolateral PFC, respectively. CONCLUSION: These findings indicate that mPFC alterations may not be substance-specific, but rather related to the number of substances used, whereas, thalamic and ventrolateral PFC pathology is specifically associated with tobacco and cocaine use, respectively. These findings are important, as the differential alterations in GM volume may underlie different cognitive deficits associated with substance use disorders.
Databáze: OpenAIRE
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