Spatially Resolved Spectral Powder Analysis: Experiments and Modeling
| Autor: | Patrick Wahl, Johannes Khinast, Boris Larchevêque, Otto Scheibelhofer, Fabien Chauchard |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Optical fiber
Materials science 010504 meteorology & atmospheric sciences Geometrical optics Scattering Mean free path Mie scattering 010401 analytical chemistry 01 natural sciences 0104 chemical sciences law.invention Wavelength law Particle Particle size Biological system Instrumentation Spectroscopy 0105 earth and related environmental sciences |
| Zdroj: | Applied spectroscopy. 72(4) |
| ISSN: | 1943-3530 |
| Popis: | Understanding the behavior of light in granular media is necessary for determining the sample size, shape, and weight when probing using fiber optic setups. This is required for a correct estimate of the active pharmaceutical ingredient content in a pharmaceutical blend via near-infrared spectroscopy. Several strategies to describe the behavior of light in granular and turbid media exist. A common approach is the Monte-Carlo simulation of individual photons and their description using mean free path lengths for scattering and absorption. In this work, we chose a complementary method by approximating these parameters via real physical counterparts, i.e., the particle size, shape, and density and the resulting chord lengths. Additionally, the wavelength dependence of refractive indices is incorporated. The obtained results were compared with those obtained in an experimental setup that included the SAM-Spec Felin probe head by Indatech for detecting spatially resolved spectra of samples. Our method facilitates the interpretation of the acquired experimental results by contrasting the optical response, the physical particle attributes, and the simulation results. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|