Rhythmic firing of medial septum non-cholinergic neurons
| Autor: | Patrice Fort, Mauro Serafin, Asaid Khateb, S. Williams, Michel Muhlethaler |
|---|---|
| Přispěvatelé: | Centre médical universitaire de Genève (CMU), Département de Physiologie, Genève, Suisse, Centre médical universitaire, Centre de recherche en neurosciences de Lyon (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 1996 |
| Předmět: |
Subthreshold membrane potential oscillations
[SDV]Life Sciences [q-bio] Guinea Pigs Hippocampus Septal Nuclei/ physiology Biology Membrane Potentials 03 medical and health sciences Membrane Potentials/drug effects/ physiology 0302 clinical medicine Cholinergic Fibers/ physiology Animals Cholinergic neuron ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences Basal forebrain General Neuroscience Long-term potentiation ddc:616.8 Rats Carbachol/ pharmacology Electrophysiology Cholinergic Fibers nervous system GABAergic Cholinergic Carbachol Septal Nuclei [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC] Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Neuroscience, Elsevier-International Brain Research Organization, 1996, 75 (3), pp.671-675. ⟨10.1016/0306-4522(96)00349-1⟩ Neuroscience, Vol. 75, No 3 (1996) pp. 671-675 |
| ISSN: | 0306-4522 1873-7544 |
| DOI: | 10.1016/0306-4522(96)00349-1 |
| Popis: | The presence of theta rhythm (5-10 Hz) in the hippocampus has been shown to enable long-term potentiation, a synaptic mechanism which has been proposed to underlie learning and memory. Medial septum cholinergic and GABAergic neurons that project to the hippocampus have been hypothesized to play conjointly a major role in the genesis of this rhythm. Building upon previous studies that have established the electrophysiological criteria for distinguishing cholinergic and non-cholinergic neurons in this area, it is demonstrated here that medial septum non-cholinergic neurons, putatively GABAergic, have the ability to discharge in rhythmic clusters of action potentials occurring at frequencies ranging from 1 to 8 Hz. Within the clusters, the firing frequency of action potentials varied between 13 and 57 Hz in a voltage-dependent manner. In addition, small voltage-dependent subthreshold membrane potential oscillations (16-54 Hz) were observed between clusters. Both subthreshold oscillations and clusters were eliminated by tetrodotoxin at 1 microM. These results indicate that non-cholinergic medial septum neurons could convey to the hippocampus not only theta but also higher frequency rhythmicity in the beta-gamma range (20-60 Hz). |
| Databáze: | OpenAIRE |
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