Neuropeptides in gut-brain axis and their influence on host immunity and stress
| Autor: | Caitlin Keller, Lingjun Li, Pingli Wei |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Biotechnology
Gut–brain axis PACAP pituitary adenylate cyclase-activating polypeptide Biophysics NPY neuropeptide Y Neuropeptide Review Article VIP vasoactive intestinal peptide Calcitonin gene-related peptide Biology CNS central nervous system Stress Biochemistry CGRP calcitonin gene-related peptide 03 medical and health sciences 0302 clinical medicine Immune system CRLR calcitonin receptor like receptor Structural Biology Immunity lcsh:TP248.13-248.65 Genetics medicine PNX phoenixin SP substance P 030304 developmental biology 0303 health sciences Hypothalamic–pituitary–adrenal axis α-MSH α-melanocyte-stimulating hormone Computer Science Applications RAMP1 receptor activity-modifying protein1 Crosstalk (biology) CRH corticotropin-releasing hormone medicine.anatomical_structure Calcitonin 030220 oncology & carcinogenesis TRPV1 transient receptor potential vanilloid receptor-1 LPS lipopolysaccharides Antimicrobial peptides ACTH adrenocorticotrophic hormone HPA axis hypothalamic–pituitary–adrenal axis Neuroscience Gut-brain axis Biotechnology |
| Zdroj: | Computational and Structural Biotechnology Journal Computational and Structural Biotechnology Journal, Vol 18, Iss, Pp 843-851 (2020) |
| ISSN: | 2001-0370 |
| Popis: | In recent decades, neuropeptides have been found to play a major role in communication along the gut-brain axis. Various neuropeptides are expressed in the central and peripheral nervous systems, where they facilitate the crosstalk between the nervous systems and other major body systems. In addition to being critical to communication from the brain in the nervous systems, neuropeptides actively regulate immune functions in the gut in both direct and indirect ways, allowing for communication between the immune and nervous systems. In this mini review, we discuss the role of several neuropeptides, including calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating polypeptide (PACAP), corticotropin-releasing hormone (CRH) and phoenixin (PNX), in the gut-brain axis and summarize their functions in immunity and stress. We choose these neuropeptides to highlight the diversity of peptide communication in the gut-brain axis. |
| Databáze: | OpenAIRE |
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