Evaluate the effects of long-term valproic acid treatment on metabolic profiles in newly diagnosed or untreated female epileptic patients: A prospective study
| Autor: | Harpreet Singh Sidhu, R. Srinivas, Akshay Sadhotra |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Blood Glucose medicine.medical_specialty Adolescent 030209 endocrinology & metabolism Lamotrigine Weight Gain Body Mass Index 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine Insulin resistance Internal medicine medicine Humans Prospective Studies Prospective cohort study Triglycerides Valproic Acid Adiponectin business.industry Triazines Cholesterol HDL General Medicine medicine.disease Endocrinology Cholesterol Neurology lipids (amino acids peptides and proteins) Anticonvulsants Female Neurology (clinical) medicine.symptom Insulin Resistance business Body mass index Weight gain 030217 neurology & neurosurgery Metabolism Inborn Errors medicine.drug |
| Zdroj: | Seizure. 48 |
| ISSN: | 1532-2688 |
| Popis: | Excessive weight gain associated with sodium valproate (VPA) may predispose patients with epilepsy to other health problems such as insulin resistance. We prospectively evaluated the long-term impact of VPA monotherapy compared with lamotrigine (LTG) monotherapy on anthropometric and metabolic parameters in women with epilepsy. Our primary objective is to understand the underlying mechanism responsible for VPA-induced obesity.Sixty-six female patients with newly diagnosed or untreated epilepsy were included in the study. Thirty-four patients with VPA and thirty-two patients with LTG were treated for a period of one year in our center. Anthropometric and clinical data were collected at 5 time points: before, at 6th week, 3rd month, 6th month, 9th month and 12th month (last visit). Biochemical and hormonal data were collected 2 time points: before and last visit.Subjects in the VPA group had significantly higher body weight than LTG-treated subjects (64.88±3.25 vs. 58.28±2.43, P0.001). HOMA-IR level was significantly increased (2.76 vs. 1.35, P0.05), and adiponectin levels were significantly lower in the VPA group (3.46 vs. 6.22, P0.05). Triglycerides levels were significantly increased (118 vs. 96, P0.05), and HDL-C levels were significantly lower in the VPA group. Both the VPA-treated group and the LTG-treated group showed no significant difference in term of total cholesterol, LDL-C, fasting blood glucose and serum leptin levels.Based on the findings of this study, we proposed that VPA induced hypoadiponectinemia which correlates significantly with insulin resistance. These two factors may be responsible for weight gain, possible by stimulating appetite. Valproic acid appears to be use cautionally in obese females with epilepsy. |
| Databáze: | OpenAIRE |
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