Effect of oxytocin administration on nerve recovery in the rat sciatic nerve damage model
| Autor: | Bilal Gümüş, Cemal Kazimoglu, Oytun Erbaş, Ersin Kuyucu, Osman Arslan Bora, Fatih Oltulu |
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| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty Pathology Drug Evaluation Preclinical Sciatic nerve Electromyography Oxytocin Rats Sprague-Dawley Peripheral Nerve Injuries Peripheral nerve Internal medicine medicine Animals Orthopedics and Sports Medicine medicine.diagnostic_test business.industry Regeneration (biology) ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS Recovery of Function Nerve injury Axons Nerve Regeneration Sprague dawley ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS Disease Models Animal ComputingMethodologies_PATTERNRECOGNITION Endocrinology Nerve growth factor Rat Surgery InformationSystems_MISCELLANEOUS medicine.symptom business Research Article medicine.drug |
| Zdroj: | Journal of Orthopaedic Surgery and Research |
| ISSN: | 1749-799X |
| Popis: | PubMed ID: 26466786 Background: Growth factors such as nerve growth factor (NGF) and insulin-like growth factor-1 (IGF-1) have been shown to play a role in the healing process of nerve injury. Recent researches have also shown that oxytocin administration activates these growth factors of importance for the healing of nerve tissue. The objective of the present study was to evaluate the effects of oxytocin on peripheral nerve regeneration in rats. Methods: Twenty-four male Sprague-Dawley rats were underwent transection damage model on the right sciatic nerve and defective damage model on the left sciatic nerve. The animals were assigned to one of two groups: control group or treatment group (received 80mg/kg oxytocin intraperitoneally for 12weeks). The sciatic nerve was examined, both functionally (on the basis of climbing platform test) and histologically (on the basis of axon count), 3, 6, 9, and 12weeks after the injury. Also, stereomicroscopic and electrophysiological evaluations were carried out. Results: Significantly greater improvements in electrophysiological recordings and improved functional outcome measures were presented in the treatment group at 12-week follow-up. Stereomicroscopic examinations disclosed prominent increases in vascularization on proximal cut edges in the oxytocin group in comparison with the control group. Higher axon counts were also found in this group. Conclusion: Intraperitoneal oxytocin administration resulted in accelerated functional, histological, and electrophysiological recovery after different sciatic injury models in rats. © 2015 Gümüs et al. |
| Databáze: | OpenAIRE |
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