Cementum and dentin in hypophosphatasia
| Autor: | Michael P. Whyte, Wouter Beertsen, T. van den Bos, G. Handoko, A. Niehof, Stephen P. Coburn, Lawrence M. Ryan |
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| Přispěvatelé: | Parodontologie (OUD, ACTA) |
| Rok vydání: | 2005 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Adolescent Periodontal Ligament Hypophosphatasia Pyrophosphate 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine stomatognathic system Internal medicine Dentin medicine Deciduous teeth Periodontal fiber Humans Cementum Cementogenesis Pyrophosphatases Child General Dentistry Dental Pulp Dental Cementum Minerals Phosphoric Diester Hydrolases Infant 030206 dentistry Dentinogenesis medicine.disease Microradiography Diphosphates stomatognathic diseases 030104 developmental biology medicine.anatomical_structure Endocrinology chemistry Case-Control Studies Child Preschool Pulp (tooth) Dental cementum Tooth Calcification |
| Zdroj: | van den Bos, T, Handoko, G, Niehof, A, Ryan, L M, Coburn, S P, Whyte, M P & Beertsen, W 2005, ' Cementum and dentin in hypophosphatasia ', Journal of Dental Research, vol. 84, pp. 1021-1025 . https://doi.org/10.1177/154405910508401110 Journal of Dental Research, 84, 1021-1025. SAGE Publications Inc. |
| ISSN: | 0022-0345 |
| Popis: | Hypophosphatasia (HPP) often leads to premature loss of deciduous teeth, due to disturbed cementum formation. We addressed the question to what extent cementum and dentin are similarly affected. To this end, we compared teeth from children with HPP with those from matched controls and analyzed them microscopically and chemically. It was observed that both acellular and cellular cementum formation was affected. For dentin, however, no differences in mineral content were recorded. To explain the dissimilar effects on cementum and dentin in HPP, we assessed pyrophosphate (an inhibitor of mineralization) and the expression/activity of enzymes related to pyrophosphate metabolism in both the periodontal ligament and the pulp of normal teeth. Expression of nucleotide pyrophosphatase phosphodiesterase 1 (NPP1) in pulp proved to be significantly lower than in the periodontal ligament. Also, the activity of NPP1 was less in pulp, as was the concentration of pyrophosphate. Our findings suggest that mineralization of dentin is less likely to be under the influence of the inhibitory action of pyrophosphate than mineralization of cementum. |
| Databáze: | OpenAIRE |
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