Prevalence of treatment-resistant psychoses in the community: A naturalistic study
| Autor: | Lucy A. Stephenson, Natasha Patel, Robert A. McCutcheon, Marcela Schilderman, Oliver D. Howes, Katherine Beck, Rosalind Ramsay |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Bipolar Disorder medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Naturalistic observation London Prevalence medicine Humans Pharmacology (medical) Bipolar disorder Psychiatry Antipsychotic Clozapine Treatment resistant Pharmacology business.industry Middle Aged medicine.disease 030227 psychiatry 3. Good health Psychiatry and Mental health Psychotic Disorders Schizophrenia Female Psychopharmacology business 030217 neurology & neurosurgery Antipsychotic Agents medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 33:1248-1253 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881119855995 |
| Popis: | Background: Treatment-resistant schizophrenia (TRS) is a major cause of disability. Clozapine is currently the only antipsychotic medication licensed for its treatment. However, the rate of treatment resistance among outpatients with schizophrenia or other psychoses, and the rate of use of clozapine among them, is not known. Aims: The aims of this study are (a) to determine the point prevalence of treatment-resistant psychosis in a community sample, and (b) to determine the number of patients with TRS who have never had a clozapine trial. Method: Clinico-demographic data were extracted from the case notes for 202 patients from two community mental-health teams. Results: We found that 56% (99/176) had a diagnosis of TRS, and 52% (51/99) of these patients had never been treated with clozapine. Patients of non-white ethnicity were less likely to have had a clozapine trial ( p=0.009). The point prevalence of treatment resistance within the bipolar affective disorder sample was 19% (5/26). Conclusion: These findings suggest that TRS is common in the community mental-health team, and a large proportion of these patients have not received clozapine. These findings indicate that identifying and treating treatment resistance should be a focus of community services for schizophrenia. |
| Databáze: | OpenAIRE |
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