Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling
| Autor: | Arisa Igarashi, Masashi Muroi, Ken-ichi Tanamoto, Tomohisa Yoshida, Takahiro Ohnishi |
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| Rok vydání: | 2008 |
| Předmět: |
Lipopolysaccharides
Microbiology (medical) Dibutyl phthalate Immunology Gene Expression Endocrine Disruptors Biology Pharmacology Diethyl phthalate Microbiology Cell Line Toxicology Mice chemistry.chemical_compound Genes Reporter Animals Immunologic Factors Immunology and Allergy Vinclozolin Atrazine Luciferases Ziram Macrophages Polysaccharides Bacterial Phthalate Methoxychlor Interferon-beta General Medicine Immunity Innate Toll-Like Receptor 4 Infectious Diseases chemistry Kepone |
| Zdroj: | FEMS Immunology & Medical Microbiology. 52:293-295 |
| ISSN: | 1574-695X 0928-8244 |
| DOI: | 10.1111/j.1574-695x.2007.00355.x |
| Popis: | Endocrine disrupting chemicals (EDCs) may potentially worsen infectious diseases because EDCs disturb human immune function by interfering with endocrine balance. To evaluate the influence of EDCs on the innate immune function of macrophages, we investigated the effects of 37 possible EDCs on lipopolysaccharide-induced activation of the IFN-beta promoter. Alachlor, atrazine, benomyl, bisphenol A, carbaryl, diethyl phthalate, dipropyl phthalate, kelthane, kepone, malathion, methoxychlor, octachlorostyrene, pentachlorophenol, nonyl phenol, p-octylphenol, simazine and ziram all inhibited the activation. Kepone and ziram showed strong inhibitory effects. Aldicarb, amitrole, benzophenone, butyl benzyl phthalate, 2,4-dichlorophenoxy acetic acid, dibutyl phthalate, 2,4-dichlorophenol, dicyclohexyl phthalate, diethylhexyl adipate, diethylhexyl phthalate, dihexyl phthalate, di-n-pentyl phthalate, methomyl, metribuzin, nitrofen, 4-nitrotoluene, permethrin, trifluralin, 2,4,5-trichlorophenoxyacetic acid and vinclozolin had no significant effects at 100 muM. These results indicate that some agrochemicals and resin-related chemicals may potentially inhibit macrophage function, which suggests that endocrine disruptors may influence the development of infectious diseases. |
| Databáze: | OpenAIRE |
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