Signaling Enzymes and Ion Channels Being Modulated by the Actin Cytoskeleton at the Plasma Membrane
| Autor: | Jong Tai Chun, Yulia Ezhova, Filip Vasilev |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
actin cytoskeleton
Cell neurons Review actin-binding protein Inositol 1 4 5-Trisphosphate immune response Ion Channels 0302 clinical medicine PIP2 Ca2+ signaling Biology (General) phospholipase C Spectroscopy 0303 health sciences biology Chemistry General Medicine Computer Science Applications Cell biology medicine.anatomical_structure Signal transduction Cell type QH301-705.5 macromolecular substances Catalysis Inorganic Chemistry 03 medical and health sciences Cell surface receptor medicine oocytes Animals Humans Actin-binding protein Calcium Signaling Physical and Theoretical Chemistry Molecular Biology QD1-999 Ion channel 030304 developmental biology Phospholipase C Organic Chemistry Cell Membrane Actin cytoskeleton Src family kinase epithelial cells biology.protein 030217 neurology & neurosurgery |
| Zdroj: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 10366, p 10366 (2021) |
| ISSN: | 1422-0067 |
| Popis: | A cell should deal with the changing external environment or the neighboring cells. Inevitably, the cell surface receives and transduces a number of signals to produce apt responses. Typically, cell surface receptors are activated, and during this process, the subplasmalemmal actin cytoskeleton is often rearranged. An intriguing point is that some signaling enzymes and ion channels are physically associated with the actin cytoskeleton, raising the possibility that the subtle changes of the local actin cytoskeleton can, in turn, modulate the activities of these proteins. In this study, we reviewed the early and new experimental evidence supporting the notion of actin-regulated enzyme and ion channel activities in various cell types including the cells of immune response, neurons, oocytes, hepatocytes, and epithelial cells, with a special emphasis on the Ca2+ signaling pathway that depends on the synthesis of inositol 1,4,5-trisphosphate. Some of the features that are commonly found in diverse cells from a wide spectrum of the animal species suggest that fine-tuning of the activities of the enzymes and ion channels by the actin cytoskeleton may be an important strategy to inhibit or enhance the function of these signaling proteins. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |