| Autor: |
Wangting, Zhou, Xuhui, Kan, Guijie, Chen, Yi, Sun, Linwu, Ran, Yamei, Yan, Jia, Mi, Lu, Lu, Xiaoxiong, Zeng, Youlong, Cao |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International Journal of Biological Macromolecules. 222:2244-2257 |
| ISSN: |
0141-8130 |
| Popis: |
In the present study, the effects of a purified fraction of polysaccharides from the fruits of Lycium barbarum L. (LBPs), named LBPs-4, on the dextran sodium sulfate (DSS)-induced colitis in mice were evaluated. The results showed that LBPs-4 decreased disease activity index score, prevented colon shortening and reduced plasma levels of pro-inflammatory cytokines (tumor necrosis factor alpha (TNF-α), interferon gamma (IFN-γ), monocyte chemoattractant protein-1 (MCP-1) and prostaglandin E2) in mice with colitis. LBPs-4 could increase the relative abundances of Akkermansia and Bifidobacterium in gut microbiota, and it also mitigated the intestinal barrier damage by upregulating the level of tight junction protein ZO-1 and the number of goblet cells in colon. Moreover, the results of in vitro culture indicated that the growth of Bifidobacterium longum subsp. infantis CCX 19042 was promoted by LBPs-4, whereas the culture media of LBPs-4 by Bacteroides ovatus with or without addition of mucin could enhance the growth of Akkermansia muciniphila. Collectively, these results suggested that LBPs-4 should be potential prebiotics for the treatment of colitis. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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