Intracerebroventricular injections of endotoxin (ET) reduces hippocampal neurogenesis
| Autor: | Batoul Darwish, Nayef E. Saadé, Farah Chamaa, Lynn Bitar, Wassim Abou-Kheir |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Neurogenesis Immunology Hippocampus Hippocampal formation Piroxicam Rats Sprague-Dawley 03 medical and health sciences Basal (phylogenetics) 0302 clinical medicine Internal medicine medicine Animals Immunology and Allergy Neuroinflammation Injections Intraventricular Inflammation business.industry Dentate gyrus Anti-Inflammatory Agents Non-Steroidal Neurodegeneration medicine.disease Rats Endotoxins 030104 developmental biology Endocrinology Neurology Hyperalgesia Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Neuroimmunology. 315:58-67 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/j.jneuroim.2017.12.013 |
| Popis: | Physio-pathological conditions such as neuroinflammation can modulate neurogenesis in the hippocampus. The aim of this study is to follow the time course of inflammation-induced effects on the neurogenic niche and the counter-effects of an anti-inflammatory drug. Rats received intracerebroventricular injections of lipopolysaccharide/endotoxin (ET) and intraperitoneal injections of 5'-bromo-2'-deoxyuridine, then perfused at different time intervals. At day 3, ET injection resulted in thermal hyperalgesia accompanied by a significant decrease in neurogenesis. A rebound of neurogenesis was detected at day 6 and levels were back to basal at day 9. Daily treatment with Piroxicam alleviated the ET-induced effects. |
| Databáze: | OpenAIRE |
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