Oxidative stress: therapeutic approaches for cervical cancer treatment
| Autor: | Lara Termini, Rafaella Almeida Lima Nunes, Francisco Aguayo, Enrique Boccardo, Mirian Galliote Morale, Gabriela Ávila Fernandes Silva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Antioxidant medicine.medical_treatment Uterine Cervical Neoplasms Context (language use) Inflammation Apoptosis Review Article medicine.disease_cause Cervical Cancer Antioxidants Malignant transformation 03 medical and health sciences 0302 clinical medicine medicine Humans Human papillomavirus Enzyme Inhibitors Tumor Markers Cervical cancer chemistry.chemical_classification Reactive oxygen species lcsh:R5-920 business.industry Papillomavirus Infections Human Papillomavirus General Medicine medicine.disease Oxidative Stress 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Redox System Female medicine.symptom business lcsh:Medicine (General) Reactive Oxygen Species Oxidative stress |
| Zdroj: | Clinics; v. 73 n. Suppl. 1 (2018); e548s Clinics; Vol. 73 Núm. Suppl. 1 (2018); e548s Clinics; Vol. 73 No. Suppl. 1 (2018); e548s Clinics Universidade de São Paulo (USP) instacron:USP Clinics, Vol 73, Iss suppl 1 (2018) |
| ISSN: | 1980-5322 1807-5932 |
| Popis: | OBJECTIVES: Oxidative stress results from an imbalance between the generation and elimination of oxidant species. This condition may result in DNA, RNA and protein damage, leading to the accumulation of genetic alterations that can favor malignant transformation. Persistent infection with high-risk human papillomavirus types is associated with inflammatory responses and reactive oxygen species production. In this context, oxidative stress, chronic inflammation and high-risk human papillomavirus can act in a synergistic manner. To counteract the harmful effects of oxidant species, protective molecules, known as antioxidant defenses, are produced by cells to maintain redox homeostasis. In recent years, the use of natural antioxidants as therapeutic strategies for cancer treatment has attracted the attention of the scientific community. This review discusses specific molecules and mechanisms that can act against or together with oxidative stress, presenting alternatives for cervical cancer prevention and treatment. |
| Databáze: | OpenAIRE |
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