| Autor: |
Michael Garrigou, Bérengère Sauvagnat, Ruchia Duggal, Nicole Boo, Pooja Gopal, Jennifer M. Johnston, Anthony Partridge, Tomi Sawyer, Kaustav Biswas, Nicolas Boyer |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of medicinal chemistry. 65(13) |
| ISSN: |
1520-4804 |
| Popis: |
Macrocyclic peptides can disrupt previously intractable protein-protein interactions (PPIs) relevant to oncology targets such as KRAS. Early hits often lack cellular activity and require meticulous improvement of affinity, permeability, and metabolic stability to become viable leads. We have validated the use of the Automated Ligand Identification System (ALIS) to screen oncogenic KRAS |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
