In vitro interactions of serotonin (5-HT) with mononuclear cells from migraine patients: alterations related to the phase of the attack
| Autor: | M. Giacovazzo, Paolo Martelletti, E. Alteri, A. Pesce, Cristina Rinaldi-Garaci |
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| Rok vydání: | 1988 |
| Předmět: |
Adult
Male Serotonin medicine.medical_specialty Adolescent Migraine Disorders Lymphocyte Immunology Cluster Headache Biology Peripheral blood mononuclear cell chemistry.chemical_compound Desensitization (telecommunications) Internal medicine medicine Humans Immunology and Allergy Binding site Neurotransmitter 5-HT receptor Middle Aged Serotonin binding Endocrinology medicine.anatomical_structure Neurology chemistry Receptors Serotonin Leukocytes Mononuclear Female Neurology (clinical) |
| Zdroj: | Journal of Neuroimmunology. 18:17-24 |
| ISSN: | 0165-5728 |
| DOI: | 10.1016/0165-5728(88)90131-2 |
| Popis: | Serotonin (5-HT) binds in a saturable and specific manner to high affinity binding sites present on the surface of human mononuclear cells. The serotonin binding to mononuclear cells has been assayed in patients with migraine, during and outside the crisis period. In these patients, unlike the episodic cluster headache patients that show a constant trend, the results are variable. This variability may depend on the fluctuation of 5-HT levels in the blood, during and after the crisis. A possible explanation for these observations is that at the beginning of the crisis the binding of 5-HT is still similar to the normal levels. As the crisis goes on, there is at first an increase in 5-HT binding that saturates all the available sites and a subsequent phenomenon of desensitization, with a loss of high affinity sites. Further investigations are needed in order to assess whether or not the mononuclear cell functions are affected by the modifications of the binding of 5-HT, though to be a regulatory molecule. |
| Databáze: | OpenAIRE |
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