Effects of a dragonfly (Anax i.) homeopathic remedy on learning, memory and cell morphology in mice
| Autor: | Sibel Kokturk, Guner Ulak, Oguz Mutlu, Furuzan Akar, Pelin Tanyeri, Faruk Erden, Ipek Komsuoglu Celikyurt |
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| Přispěvatelé: | Mutlu, O, Ulak, G, Kokturk, S, Celikyurt, IK, Tanyeri, P, Akar, F, Erden, F, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Tanyeri, Pelin |
| Rok vydání: | 2016 |
| Předmět: |
Male
0301 basic medicine Odonata Morris water navigation task Physiology Integrative & Complementary Medicine Escape latency Cell morphology Toxicology Mice 03 medical and health sciences 0302 clinical medicine Memory Animals Medicine Learning memory Maze Learning Probe trial Mice Inbred BALB C Dose-Response Relationship Drug biology business.industry fungi food and beverages Homeopathy Dragonfly biology.organism_classification Pyrrolidonecarboxylic Acid 030104 developmental biology Complementary and alternative medicine Insect Hormones Escape platform Homeopathic remedy Materia Medica business Oligopeptides 030217 neurology & neurosurgery |
| Zdroj: | Homeopathy. 105:96-101 |
| ISSN: | 1475-4916 |
| Popis: | Background Homeopathy is a form of alternative medicine in which uses highly diluted preparations that are believed to cause healthy people to exhibit symptoms similar to those exhibited by patients. The aim of this study was to investigate the effects of dragonfly (Anax imperator, Anax i.) on learning and memory in naive mice using the Morris water maze (MWM) test; moreover, the effects of dragonfly on MK-801-induced cognitive dysfunction were evaluated. Methods Male balb-c mice were treated with dragonfly (30C and 200C) or MK-801 (0.2 mg/kg) alone or concurrently (n = 10). Dragonfly (D) and MK-801 were administered subchronically for 6 days intraperitoneally 60 min and 30 min, respectively, before the daily performance of the MWM test. Results This study revealed that in the familiarization session and first session of the MWM test, Anax i. D30 significantly decreased escape latency compared to the control group, although MK-801, D30 and D200 significantly increased escape latency at the end of five acquisition sessions. Anax i. combined with dizocilpine maleate (MK-801) also significantly decreased escape latency in the familiarization session and first session of the MWM test, although this combination increased escape latency compared to the MK-801 alone group at the end of the test. Time spent in escape platform's quadrant in the probe trial significantly decreased while mean distance to platform significantly increased in MK-801, D30 and D200 groups. In the MWM test, Anax i. combined with MK-801 significantly decreased speed of the animals compared to the MK-801 alone group. General cell morphology was disturbed in the MK-801 group while D30 and D200 seemed to improve cell damage in the MK-801 group. Conclusions These results suggest that the homeopathic Anax i. can impair learning acquisition and reference memory, and it has beneficial effects on disturbed cell morphology. |
| Databáze: | OpenAIRE |
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