Pro- and Anti-Inflammatory Cytokine Balance in Major Depression: Effect of Sertraline Therapy
| Autor: | Adnan Cansever, Ali Bozkurt, Ugur Musabak, Özcan Uzun, S. Yavuz Sanisoglu, Aytekin Özşahin, Zeki Yesilova, Nahit Ozmenler, Levent Sütçigil, Cagatay Oktenli, Ali Sengul |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male lcsh:Immunologic diseases. Allergy Chemokine Article Subject medicine.drug_class medicine.medical_treatment education Immunology Enzyme-Linked Immunosorbent Assay behavioral disciplines and activities Anti-inflammatory Proinflammatory cytokine Transforming Growth Factor beta1 Sertraline mental disorders Immunology and Allergy Medicine Humans In patient Depression (differential diagnoses) Chemokine CCL2 Depressive Disorder Major biology business.industry Tumor Necrosis Factor-alpha General Medicine Interleukin-12 Antidepressive Agents Cytokine biology.protein Clinical Study Antidepressant Cytokines Interleukin-2 Female Interleukin-4 business lcsh:RC581-607 psychological phenomena and processes medicine.drug |
| Zdroj: | Clinical and Developmental Immunology, Vol 2007 (2008) Clinical and Developmental Immunology, Vol 2007 (2007) Clinical and Developmental Immunology |
| ISSN: | 1740-2530 1740-2522 |
| Popis: | The specific associations between antidepressant treatment and alterations in the levels of cytokines remain to be elucidated. In this study, we aimed to explore the role of IL-2, IL-4, IL-12, TNF-α, TGF-β1, and MCP-1 in major depression and to investigate the effects of sertraline therapy. Cytokine and chemokine levels were measured at the time of admission and 8 weeks after sertraline treatment. Our results suggest that the proinflammatory cytokines (IL-2, IL-12, and TNF-α) and MCP-1 were significantly higher, whereas anti-inflammatory cytokines IL-4 and TGF-β1 were significantly lower in patients with major depression than those of healthy controls. It seems likely that the sertraline therapy might have exerted immunomodulatory effects through a decrease in the proinflammatory cytokine IL-12 and an increase in the anti-inflammatory cytokines IL-4 and TGF-β1. In conclusion, our results indicate that Th1-, Th2-, and Th3-type cytokines are altered in the depressed patients and some of them might have been corrected by sertraline treatment. |
| Databáze: | OpenAIRE |
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